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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 407 - 419 (13page)
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Dendritic cells (DCs) play a role in natural killer (NK) cell activation, while NK cells are also able to activate and mature DCs. Toll-like receptors (TLRs) on the surface of DCs and NK cells induce the maturation and activation of these cells when engaged with their cognate ligand. We investigated to generate potent DCs by maturation with NK cells in the presence of TLR agonist in vitro and tested the efficacy of these DC vaccinations in mouse colon cancer model. The optimal ratios of DCs versus NK cells were 1:1 to 1:2. Immature DCs were mature with NK cells in the presence of lipopolysaccharide,which is TLR4 agonist, and further addition of IL-2 induced phenotypically and functionally mature bone marrow-derived DCs. These potent DCs exhibited not only high expression of several costimulatory molecules and high production of IL-12p40and IL-12p70, but also high allogeneic T cells stimulatory capacity, and the induction of the high activities to generate tumor-specific CTLs. Consistently, vaccination with these DCs efficiently inhibited CT-26 tumor growth in mouse colon cancer model when compared to other vaccination strategies. Interestingly, combination therapy of these DC-based vaccines and with low-dose cyclophosphamide showed dramatic inhibition effects of tumor growth. These results suggest that the DCs maturated with NK cells in the presence of TLR agonist are potent inducer of antitumor immune responses in mouse model and may provide a new source of DC-based vaccines for the development of immunotherapy against colon cancer.
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참고문헌 (23)
참고문헌 신청
Akira S / 2003 / Recognition of pathogen-associated molecular patterns by TLR family / Immunol Lett 85 : 85 ~ 95
Andrews DM / 2003 / Functional interactions between dendritic cells and NK cells during viral infection / Nat Immunol 4 : 175 ~ 181
Berd D / 1984 / Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide / Cancer Res 44 : 5439 ~ 5443
Chalifour A / 2004 / Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production / Blood 104 : 1778 ~ 1783
Cooper MA / 2004 / NK cell and DC interactions / Trends Immunol 25 : 47 ~ 52
Andrews DM / 2003 / Functional interactions between dendritic cells and NK cells during viral infection / Nat Immunol 4 : 175 ~ 181
Berd D / 1984 / Potentiation of human cell-mediated and humoral immunity by low-dose cyclophosphamide / Cancer Res 44 : 5439 ~ 5443
Chalifour A / 2004 / Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production / Blood 104 : 1778 ~ 1783
Cooper MA / 2004 / NK cell and DC interactions / Trends Immunol 25 : 47 ~ 52
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