지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제8호
- 발행연도
- 2013.1
- 수록면
- 1,159 - 1,166 (8page)
이용수
초록· 키워드
오류제보하기
Orientia tsutsugamushi, a gram-negative bacterium, causes severe acute febrile illness in humans. Despite this danger, the route of infection, infectivity, and protective mechanisms of the host’s immune response to O. tsutsugamushi are unclear. Dendritic cells (DCs) are one of the most important cell types in bridging the innate and adaptive immune responses. In this study, we observed that O. tsutsugamushi infects and replicates in monocyte-derived DCs (MODCs). During infection and replication, the expressions of the cytokines IL-12 and TNF-α,as well as the co-stimulatory molecules CD80, CD83, CD86, and CD40, were increased in MODCs. When O. tsutsugamushi-treated MODCs were co-cultured with autologous CD4+ T cells, they enhanced production of IFN-γ, a major Th1 cytokine. Collectively, our results show that O. tsutsugamushi can replicate in MODCs and can simultaneously induce MODC maturation and increase proinflammatory cytokine levels in MODCs that subsequently activate CD4+ T cells.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
Birmingham CL / 2008 / Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system / Autophagy 4 : 368 ~ 371
Choi NJ / 1998 / Apoptosis of murine macrophage-like cells infected with Orientia tsutsugamushi / J. Korean Soc. Microbiol 33 : 399 ~ 406
Chu H / 2006 / Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes / Infect. Immun 74 : 4246 ~ 4253
De Trez C / 2005 / TLR4 and Toll-IL-1 receptor domaincontaining adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apop
Birmingham CL / 2008 / Avoiding death by autophagy: interactions of Listeria monocytogenes with the macrophage autophagy system / Autophagy 4 : 368 ~ 371
Choi NJ / 1998 / Apoptosis of murine macrophage-like cells infected with Orientia tsutsugamushi / J. Korean Soc. Microbiol 33 : 399 ~ 406
Chu H / 2006 / Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes / Infect. Immun 74 : 4246 ~ 4253
De Trez C / 2005 / TLR4 and Toll-IL-1 receptor domaincontaining adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apop
이 논문의 저자 정보
최근 본 자료
댓글(0)
0