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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 44 - 58 (15page)
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Silibinin is the major active molecule of silymarin, the mixture of flavonolignans extracted from Cirsium japonicum (CJ). It has been used for treatment of hepatitis and inflammation related diseases. The aim of this study was to prove whether Silibinin has effectiveness for allergic inflammation. Silibinin processes the inflammatory reaction in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (PMA plus A23187) stimulated human mast cell line (HMC-1). Its effect was examined by ELISA, RT-PCR, Western blot,and Luciferase assay. The results were Silibinin inhibited the expression of histamine, TNF-α (tumor necrosis factor-α), IL-6 (interleukin-6), and IL-8 (interleukin-8). Silibinin suppressed NF-κB (nuclear factor kappa B) activation in stimulated HMC-1 (human mast cell-1). This effect was mediated through inhibition of phosphorylation and degradation of IkBα, an inhibitor of NF-kB. Silibinin significantly inhibited induction of NF-kB promoter mediated Luciferase assay. These results suggest that Silibinin has a potential molecule for therapy of mast cell-derived allergic inflammatory diseases.
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참고문헌 (30)
참고문헌 신청
Beg, A. A / 1993 / The I kappa B protein: multifunctional regulators of Re 1/NF-kappa B transcription factor / Genes Dev 7 (11) : 2064 ~ 2070
Bodreau, R. T / 2004 / Phosphatase inhibition potentiates IL-6 production by mast cells in response to Fc εRI-mediated activation: involvement of p38 MAPK / J Leukoc Biol 76
Chen, F. E / 1998 / Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA / Nature 391 : 410 ~ 413
Galien, R / 1996 / Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding site in interleukin-6 promoter inhibition by estrogens / Mol Endocrinol 1
Goldsby, R. A / 2006 / KUBY 면역학 / 월드사이언스 : 263 ~ 405
Bodreau, R. T / 2004 / Phosphatase inhibition potentiates IL-6 production by mast cells in response to Fc εRI-mediated activation: involvement of p38 MAPK / J Leukoc Biol 76
Chen, F. E / 1998 / Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA / Nature 391 : 410 ~ 413
Galien, R / 1996 / Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding site in interleukin-6 promoter inhibition by estrogens / Mol Endocrinol 1
Goldsby, R. A / 2006 / KUBY 면역학 / 월드사이언스 : 263 ~ 405
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Silibinin Induces Apoptotic Cell Death Via ROS-dependent Mitochondrial Pathway in Human Glioma Cells
동의생리병리학회지
2009 .01
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Immunosuppressive Effect of Silibinin in Experimental Autoimmune Encephalomyelitis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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Protective Effects of Silibinin and Its Possible Mechanism of Action in Mice Exposed to Chronic Unpredictable Mild Stress
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Combined treatment of silibinin with either sorafenib or EGFR tyrosine kinase inhibitors enhances growth inhibitory effects in hepatocellular carcinoma cells
Clinical and Molecular Hepatology
2015 .01
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Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells
Annals of Surgical Treatment and Research
2014 .09
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Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Silibinin attenuates radiation-induced intestinal fibrosis
한국실험동물학회 학술발표대회 논문집
2018 .07
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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
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Silibinin Inhibits Proliferation, Induces Apoptosis and Causes Cell Cycle Arrest in Human Gastric Cancer MGC803 Cells Via STAT3 Pathway Inhibition
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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大薊가 LPS로 유도된 Mouse BV2 Microglial cells의 염증반응에 미치는 영향
대한한방내과학회지
2008 .01
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Determination of Silibinin in human plasma by high performance liquid chromatography: validation and application in pharmacokinetic study
대한약학회 학술대회
2001 .01
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Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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大薊와 실리비닌의 Mouse BV2 Microglial Cells에서 Lipopolysaccharide에 의해 유발된 염증반응에 대한 신경보호 효과
대한한방내과학회지
2007 .01
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Silibinin attenuates silica dioxide nanoparticles-induced inflammation by suppressing TXNIP/MAPKs/AP-1 signaling
한국실험동물학회 학술발표대회 논문집
2020 .07
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Silibinin attenuates silica dioxide nanoparticles-induced inflammation by suppressing TXNIP/MAPK/AP-1 signaling
한국실험동물학회 학술발표대회 논문집
2020 .02
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Silibilin-Induces Apoptosis in Breast Cancer Cells by Modulating p53, p21, Bak and Bcl-xl Pathways
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Silibinin Induces Apoptotic Cell Death Via ROS-dependent Mitochondrial Pathway in Human Glioma Cells
동의생리병리학회지
2009 .08
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TPA-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2
대한외과학회 학술대회 초록집
2009 .11
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Preparation, Characterization and Cytotoxicity of Silibinin-Containing Nanoniosomes in T47D Human Breast Carcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Silibinin enhances C/EBP$\alpha$ and PPARY expression and induces differentiation of 3T3-L1 preadipocytes
대한약학회 학술대회
2001 .01
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