지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 166 - 175 (10page)
이용수
초록· 키워드
오류제보하기
Objectives : This study was designed to evaluate the neuroprotective effect of Cirsium japonicum and Silibinin on lipopolysaccharide-induced inflammation in BV2 microglial cells.
Methods : We studied on the neuroprotective effect of lipopolysaccharide-induced inflammation using MTS assay, western blot, and nitric oxide detection on mouse BV2 microglial cells.
Results : Cirsium japonicum dose-dependently (50㎍/ml～250㎍/ml) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglia and also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot.
Silibinin dose-dependently (10μM～100μM) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglial cells. Silibinin also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot.
Conclusion : These effects of neuroprotection related to anti-inflammation suggest that Cirsium japonicum and Silibininmay be useful candidates for the development of a drug for related neurodegenerative diseases.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1992 / Activated microglia mediate neuronal cell injury via a nitric oxide mechanism 149
/ 1994 / Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons : 1485 ~ 8
/ 1994 / Nitric oxide:a physiologic messenger molecule 63
/ 1994 / Reactive nitrogen intermeditates in human neuropathology : 152 ~ 61
/ 1994 / Regulation of biosynthesis of nitrite oxide
/ 1994 / Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons : 1485 ~ 8
/ 1994 / Nitric oxide:a physiologic messenger molecule 63
/ 1994 / Reactive nitrogen intermeditates in human neuropathology : 152 ~ 61
/ 1994 / Regulation of biosynthesis of nitrite oxide
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
大薊가 LPS로 유도된 Mouse BV2 Microglial cells의 염증반응에 미치는 영향
대한한방내과학회지
2008 .01
-
Inhibitory Action of Minocycline on Lipopolysaccharide-Induced Release of Nitric Oxide and Prostaglandin E2 in BV2 Microglial Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
창출 추출물의 BV2 cell 소염작용에 관한 실험적 연구
한방안이비인후피부과학회지
2007 .01
-
大薊의 주성분인 Silibinin이 알레르기 염증반응에 미치는 效果
한방안이비인후피부과학회지
2010 .01
-
Harpagophytum Procumbens Suppresses Lipopolysaccharide Induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
대한한의학회지
2005 .12
-
Schizandra chinensis Alkaloids Inhibit Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2009 .01
-
Effects of the Aqueous Extract of Rehmanniae Radix Preparata on Lipopolysaccharide-induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
동의생리병리학회지
2006 .08
-
Effects of the Aqueous Extract of Rehmanniae Radix Preparata on Lipopolysaccharide-induced Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells
동의생리병리학회지
2006 .01
-
Effect of Ethanol Extracts from Defatted Perilla frutescens on LPS-induced Inflammation in Mouse BV2 Microglial Cells
대한의생명과학회지
2018 .12
-
지질다당체유도 BV2세포손상에 대한 상백피 추출물의 항염증작용
동의생리병리학회지
2010 .06
-
Genome Wide Expression Profile of Asiasarum sieboldi in LPS-stimulated BV-2 Microglial Cells
Molecular & cellular toxicology
2008 .01
-
지질다당체유도 BV2세포손상에 대한 상백피 추출물의 항염증작용
동의생리병리학회지
2010 .01
-
Genome Wide Expression Profile of Agrimonia pilosa in LPS-stimulated BV-2 Microglial Cells
Molecular & cellular toxicology
2009 .01
-
Clematis chinensis suppresses lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in mouse BV2 microglial cells
Oriental pharmacy and experimental medicine
2010 .01
-
Effects of Anemarrhenae Rhizoma on LPS-stimulated Expression of COX-2 and iNOS in mouse BV2 microglial cells
대한침구의학회지
2005 .01
-
Anti-neuroinflammatory effect of MHC01 on lipopolysaccharide-stimulated microglial cells
한국실험동물학회 학술발표대회 논문집
2020 .07
-
삼묘환(三妙丸)의 LPS에 의해 활성화된 RAW 264.7 cells과 BV-2 Microglia cells로부터 생성되는 nitric oxide 및 $TNF-{\alpha}$의 생성억제효과
대한본초학회지(본초분과학회지)
2006 .01
-
Human placental extract suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells
대한침구의학회지
2005 .01
-
Silibinin Induces Apoptotic Cell Death Via ROS-dependent Mitochondrial Pathway in Human Glioma Cells
동의생리병리학회지
2009 .01
-
오령산가온비탕의 BV2에서 LPS로 유도된 nitric oxide 및 $TNF-{\alpha}$ 생성에 미치는 영향
대한본초학회지(본초분과학회지)
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0