Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells

Nasiri, Marzieh; Zarghami, Nosratollah; Koshki, Kazem Nejati; Mollazadeh, Mahdieh; Moghaddam, Mohammad Pourhassan; Yamchi, Mohammad Rahmati; Esfahlan, Rana Jahanban; Barkhordari, Amin; Alibakhshi, Abbas

추천

검색

자료유형: 학술저널

저자정보: Nasiri, Marzieh (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Zarghami, Nosratollah (Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences) Koshki, Kazem Nejati (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Mollazadeh, Mahdieh (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Moghaddam, Mohammad Pourhassan (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Yamchi, Mohammad Rahmati (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Esfahlan, Rana Jahanban (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences) Barkhordari, Amin (Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz Universit) Alibakhshi, Abbas

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,449 - 3,453 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Telomerase has been considered as an attractive molecular target for breast cancer therapy. The main objective of this work is to assess the inhibitory effects of silibinin and curcumin, two herbal substances, on telomerase gene expression in breast cancer cells. Materials and Methods: For determination of cell viability tetrazolium-based assays were conducted after 24, 48, and 72 h exposure times and expression of human telomerase reverse transcriptase gene was measured with real-time PCR. Results: Each compound exerted cytotoxic effects on T47D cells and inhibited telomerase gene expression, both in a time-and dose-dependent manner. The mixture of curcumin and silibinin showed relatively more inhibitory effect on growth of T47D cells and hTERT gene expression as compared with either agent alone. Conclusions: These findings suggest that cell viability along with hTERT gene expression in breast cancer cells could be reduced by curcumin and silibinin.

#Curcumin #silibinin #breast cancer #telomerase

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Nasiri, Marzieh

소속기관 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabri