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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 245 - 250 (6page)
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초록· 키워드
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Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having anti-hepatotoxic and anticancer properties. In this paper, we investigated the effects of silibinin on behavior and neuroplasticity in mice subjected to chronic unpredictable mild stress (CUMS). After 5 consecutive weeks of CUMS, the mice were treated with silibinin (100 mg/kg, 200 mg/kg and 400 mg/kg by oral gavage) for 3 consecutive weeks. The results showed that silibinin administration significantly alleviated the CUMS-induced depressive-like behavior, including the total number of squares crossed and the frequency of rearing in the open field test, the immobility time in the tail suspension test and the forced swimming test. Furthermore, silibinin treatment increased the levels of brain-derived neurotrophic factor (BDNF), serotonin (5-HT) and norepinephrine (NE) in the prefrontal cortex and hippocampus. Our study provides new insight into the protective effects of silibinin on the depressive status of CUMS mice, specifically by improving neuroplasticity and neurotransmission.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Acheson, A. / 1995 / A BDNF autocrine loop in adult sensory neurons prevents cell death / Nature 374:450~453
Agarwal, C. / 2013 / Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship / PloS One 8:e60074
Ahmad, A. / 2010 / Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress / Stress 13:355~364
Bekinschtein, P. / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc. Natl. Acad. Sci. U.S.A 105:2711~2716
Bergami, M. / 2012 / A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus / Dev. Neurobiol 72:1016~1031
Agarwal, C. / 2013 / Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship / PloS One 8:e60074
Ahmad, A. / 2010 / Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress / Stress 13:355~364
Bekinschtein, P. / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc. Natl. Acad. Sci. U.S.A 105:2711~2716
Bergami, M. / 2012 / A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus / Dev. Neurobiol 72:1016~1031
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