지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 687 - 692 (6page)
이용수
초록· 키워드
오류제보하기
Objective: Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently, MIR137, CACNA1C, CSMD1, DRD2, and GRM3 have been reported as the most robustly emerging candidates involved in the etiology of schizophrenia. In this case control study, we performed an association analysis of rs1625579 (MIR137), rs1006737, rs4765905 (CACNA1C), rs10503253 (CSMD1), rs1076560 (DRD2), rs12704290, rs6465084, and rs148754219 (GRM3) in Pakistani population.
Methods: Schizophrenia was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV). Detailed clinical information, family history of all patients and healthy controls were collected. RFLP based case control association study was performed in a Pakistani cohort of 508 schizophrenia patients and 300 healthy control subjects. Alleles and genotype frequencies were calculated using SPSS.
Results: A significant difference in the genotype and allele frequencies for rs4765905, rs1076560 and rs6465084 were found between the patients and controls (p=0.000).
Conclusion: This study provides substantial evidence supporting the role of CACNA1C, GRM3 and DRD2 as schizophrenia susceptibility genes in Pakistani population.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Nyegaard M / 2010 / CACNA1C(rs1006737)is associated with schizophrenia / Mol Psychiatry 15:119~121
Erk S / 2010 / Brain function in carriers of a genome-wide supported bipolar disorder variant / Arch Gen Psychiatry 67:803~811
Soeiro-de-Souza MG / 2013 / The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder / Acta Psychiatr Scand 128:362~269
Erk S / 2014 / Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects / Neuroimage 94:147~154
Krug A / 2014 / A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval / Eur Arch Psychiatry Clin Neurosci 264:103~110
Erk S / 2010 / Brain function in carriers of a genome-wide supported bipolar disorder variant / Arch Gen Psychiatry 67:803~811
Soeiro-de-Souza MG / 2013 / The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder / Acta Psychiatr Scand 128:362~269
Erk S / 2014 / Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects / Neuroimage 94:147~154
Krug A / 2014 / A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval / Eur Arch Psychiatry Clin Neurosci 264:103~110
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