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MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.24 KCI Accredited Journals
- 발행연도
- 2022.6
- 수록면
- 1 - 13 (13page)
- DOI
- 10.3346/jkms.2022.37.e197
이용수
MicroRNA Expression in Plasma of Esophageal Squamous Cell Carcinoma Patients
초록· 키워드
오류제보하기
Background: Patients with esophageal squamous cell carcinoma (ESCC) have a poor prognosis and there are no effective clinical biomarkers. Recently, stable microRNAs detected in the blood have been suggested as potential biomarkers in various cancers. Therefore, we investigated whether plasma microRNAs could be feasible biomarkers for ESCC.
Methods: Peripheral blood samples were obtained from 16 healthy volunteers and 66 ESCC patients before treatment between May 2016 and April 2021. Plasma miR-18b, miR-21, miR31, and miR-375 expression levels were measured using reverse transcription-quantitative polymerase chain reaction.
Results: Compared with those in healthy controls, the expression levels of plasma miR-21 were significantly higher (P = 0.022) and those of plasma miR-31 and miR-375 were significantly lower in ESCC patients (both P < 0.001). Plasma miR-18b expression levels increased in ESCC patients, but the difference was not significant (P = 0.164). The sensitivities and specificities of miR-21, miR-31, and miR-375 for differentiating ESCC patients from healthy controls were 87.5% and 61.9%, 87.5% and 98.4%, and 87.5% and 100%, respectively. There was no difference in expression levels of plasma miR-21, miR-31, and miR-375 according to clinicopathological characteristics of sex, age, tumor size and location, histologic grade, and tumor-node-metastasis stage.
Conclusion: Our study demonstrated that plasma miR-21, miR-31, and miR-375 could be potential biomarkers for the diagnosis of ESCC. Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls.
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