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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 945 - 950 (6page)
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초록· 키워드
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Purpose: This study aimed to screen for differentially expressed microRNAs (miRNAs) in the colons of rats with visceral hypersensitivityto build the expression profiles of miRNAs therein and to determine the mechanism of Tongxieyaofang use in thetreatment of irritable bowel syndrome (IBS). Materials and Methods: Forty Sprague-Dawley rats were divided randomly into four groups: control group, model control group(induced by rectum stimulus and evaluated by abdominal withdraw reaction), treatment control group (normal saline), andTongxieyaofang group (treated with Tongxieyaofang). We screened for differential expression of colonic mucosal miRNAs usingliquid chip technology and verified the expression thereof using reverse transcription-PCR. Results: The visceral hypersensitivity rat model was successfully established. We found the expression of let-7f, let-7i, miR-130b,miR-29a, miR-132, miR-21, and miR-375 to be up-regulated (p<0.05), while the expression of miR-24, miR-31a, miR-192, miR-221,and miR-223 was down-regulated (p<0.05) in the visceral hypersensitivity rats. After treatment with Tongxieyaofang, the expressionof let-7f, let-7i, miR-130b, miR-29a, miR-132, miR-21, and miR-375 was reduced (p<0.05), whereas the expression of miR-24,miR-31a, miR-192, miR-221, miR-223 was increased, compared to the treatment control group (p<0.05). Conclusion: MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang.
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참고문헌 (38)
참고문헌 신청
Longstreth GF / 2006 / Functional bowel disorders / Gastroenterology 130:1480~1491
Verne GN / 2001 / Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome / Pain 93:7~14
Zhou Q / 2009 / Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome / Pain 146:41~46
Camilleri M / 2010 / Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion / Neurogastroenterol Motil 22:e15~e26
Zhou Q / 2011 / New insights into visceral hypersensitivity--clinical implications in IBS / Nat Rev Gastroenterol Hepatol 8:349~355
Verne GN / 2001 / Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome / Pain 93:7~14
Zhou Q / 2009 / Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome / Pain 146:41~46
Camilleri M / 2010 / Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion / Neurogastroenterol Motil 22:e15~e26
Zhou Q / 2011 / New insights into visceral hypersensitivity--clinical implications in IBS / Nat Rev Gastroenterol Hepatol 8:349~355
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