지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제3호
- 발행연도
- 2019.1
- 수록면
- 364 - 368 (5page)
이용수
초록· 키워드
오류제보하기
Objective: Genetics factors are likely to play a role in the risk, clinical presentation and treatment outcome in major depressive disorder (MDD). In this study, we investigated the role of three candidate genes for MDD; calcium voltagegated channel subunit alpha1 C (CACNA1C ), cholinergic receptor nicotinic alpha 7 subunit (CHRNA7 ), and mitogenactivated protein kinase 1 (MAPK1 ). Methods: Two-hundred forty-two MDD patients and 326 healthy controls of Korean ancestry served as samples for the analyses. Thirty-nine single nucleotide polymorphisms (SNPs) within CACNA1C, CHRNA7, and MAPK1 genes were genotyped and subsequently tested for association with MDD (primary analysis) and other clinical features (symptoms’ severity, age of onset, history of suicide attempt, treatment outcome) (secondary analyses). Single SNPs, haplotypes and epistatic analyses were performed. Results: Single SNPs were not associated with disease risk and clinical features. However, a combination of alleles (haplotype) within MAPK1 was found associated with MDD-status. Secondary analyses detected a possible involvement of CACNA1C haplotype in resistance to antidepressant treatment. Conclusion: These data suggest a role for MAPK1 and CACNA1C in MDD risk and treatment resistance, respectively. However, since many limitations characterize the analysis, the results must be considered with great caution and verified.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Berrios GE / 1985 / The psychopathology of affectivity : conceptual and historical aspects / Psychol Med 15:745~758
Otte C / 2016 / Major depressive disorder / Nat Rev Dis Primers 2:16065
Alessandro Serretti / 2018 / The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants / Clinical Psychopharmacology and Neuroscience 16(1):1~6
Jikuang Zhao / 2017 / Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis / Clinical Psychopharmacology and Neuroscience 15(1):53~58
Krishnan V / 2010 / Linking molecules to mood : new insight into the biology of depression / Am J Psychiatry 167:1305~1320
Otte C / 2016 / Major depressive disorder / Nat Rev Dis Primers 2:16065
Alessandro Serretti / 2018 / The Present and Future of Precision Medicine in Psychiatry: Focus on Clinical Psychopharmacology of Antidepressants / Clinical Psychopharmacology and Neuroscience 16(1):1~6
Jikuang Zhao / 2017 / Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis / Clinical Psychopharmacology and Neuroscience 15(1):53~58
Krishnan V / 2010 / Linking molecules to mood : new insight into the biology of depression / Am J Psychiatry 167:1305~1320
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Association of CACNA1C Variants with Bipolar Disorder in the Korean Population
PSYCHIATRY INVESTIGATION
2016 .01
-
BeMicroarray Analysis of the Major Depressive Disorder mRNA Profile Data
PSYCHIATRY INVESTIGATION
2015 .01
-
성인 아토피 피부염 환자의 우울증 동반에 따른 점증적 비용 부담: 후향적 단면연구
보건의료기술평가
2021 .12
-
Multiple Complement Pathway-related Proteins Might Regulate Immunopathogenesis of Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2023 .05
-
Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
Journal of Korean Medical Science
2019 .01
-
Serum Cytokine Levels in Major Depressive Disorder and Its Role in Antidepressant Response
PSYCHIATRY INVESTIGATION
2016 .01
-
Gender Differences in Depressive Symptom Profile: Results from Nationwide General Population Surveys in Korea
Journal of Korean Medical Science
2015 .01
-
Comparison of Electroencephalography (EEG) Coherence between Major Depressive Disorder (MDD) without Comorbidity and MDD Comorbid with Internet Gaming Disorder
Journal of Korean Medical Science
2017 .01
-
Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update
전남의대학술지
2016 .01
-
Diagnostic Issues of Depressive Disorders from Kraepelinian Dualism to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
PSYCHIATRY INVESTIGATION
2019 .01
-
Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical Variables
PSYCHIATRY INVESTIGATION
2020 .01
-
The Relationship of Lifestyle Factors with the Prevalence of Major Depressive Disorder by Ecological Factors
PSYCHIATRY INVESTIGATION
2021 .01
-
Expected Emotional Usefulness and Emotional Preference in Individuals with Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Biomarkers of Major Depressive Disorder: Knowing is Half the Battle
Clinical Psychopharmacology and Neuroscience
2021 .01
-
조현병과 제1형 양극성장애의 진단 경계를 넘어선 공통적 후보유전자로서의CACNA1C 에 대한 단일염기다형성 연합 연구
대한조현병학회지
2018 .01
-
Frontal Alpha Asymmetry Moderated by Suicidal Ideation in Patients with Major Depressive Disorder: A Comparison with Healthy Individuals
Clinical Psychopharmacology and Neuroscience
2020 .01
-
Reduced Temporal Activation During a Verbal Fluency Task is Associated with Poor Motor Speed in Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Comparison of Autonomic Reactivity to the Stress between Adjustment Disorder and Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Association Between the C4 Binding Protein Level and White Matter Integrity in Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2022 .09
-
주요우울장애를 동반한 공황장애 환자군의 임상적 특징
생물정신의학
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0