지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives This study was aimed to investigate the association between amisulpride-induced hyperprolactinemia and the Taq1A polymorphism in the D2 dopamine receptor gene (DRD2) in schizophrenic patients. Methods The plasma concentrations of prolactin were measured before and after treatment with amisulpride in one hundred and twenty-five schizophrenic patients. The effect of the Taq1A variants of the DRD2 on the risk of amisulpride-induced hyperprolactinemia was the main the outcome measure. The genotyping for Taq1A (rs1800497) polymorphism was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay. Results There was a significant difference between the prolactin level at baseline and the 6th week after treatment with amisulpride in all the subjects. However, there were no significant correlations between ΔProlactin (the difference between prolactin level at baseline and the 6th week after treatment) and the Taq1A genotypes. Conclusions This is the first study to investigate the-correlations between the Taq1A polymorphism and the amisulpride-induced hyperprolactinemia in Korean schizophrenic patients. The current results suggested the further large-scale researches on various SNPs in the DRD2 gene will establish clear goals and provide answers to the unanswered questions described in this study.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Rubin RT / 1987 / Psychopharmacology:the third generation of progress / Raven Press :803~808
Halbreich U / 2003 / Elevated prolactin levels in patients with schizophrenia: mechanisms and related adverse effects / Psychoneuroendocrinology 28(1):53~67
Clemens JA / 1978 / Evidence that serotonin neurons stimulate secretion of prolaction releasing factor / Life Sci 22:2209~2213
Claghorn J / 1987 / The risks and benefits of clozapine versus chlor promazine / J Clin Psychopharmacol 7:377~384
Wirshing DA / 2000 / Nonextrapyramidal side effects of novel antipsychotics / Curr Opin Psychiatry 13:45~50
Halbreich U / 2003 / Elevated prolactin levels in patients with schizophrenia: mechanisms and related adverse effects / Psychoneuroendocrinology 28(1):53~67
Clemens JA / 1978 / Evidence that serotonin neurons stimulate secretion of prolaction releasing factor / Life Sci 22:2209~2213
Claghorn J / 1987 / The risks and benefits of clozapine versus chlor promazine / J Clin Psychopharmacol 7:377~384
Wirshing DA / 2000 / Nonextrapyramidal side effects of novel antipsychotics / Curr Opin Psychiatry 13:45~50
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