메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제19권 제3호
발행연도
2019.1
수록면
315 - 328 (14page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Purpose: To investigate the clinical value of serum miR-221-3p and miR-122-5p expressionlevels in the diagnosis and prognosis of gastric cancer. Materials and Methods: Serum samples from 141 gastric cancer cases (gastric cancergroup), 110 gastric polyps (gastric polyp group), and 75 healthy people (healthy control) wereused to detect miR-221-3p and miR-122-5p expression using real-time reverse transcriptionpolymerase chain reaction. Results: Serum miR-221-3p expression was significantly higher in the gastric cancer groupthan in the gastric polyp group, and it was significantly lower than that before operation. The miR-221-3p expression was significantly higher in the death group than in the survivalgroup. The proliferation and migration ability significantly increased and the apoptosis ratesignificantly decreased by miR-221-3p transfection in gastric cancer cells. In contrast, thefunction of miR-122-5p in gastric cancer cells was opposite of miR-221-3p. Serum miR-221-3p expression was negatively correlated with that of miR-122-5p in gastric cancer. SerummiR-221-3p and miR-122-5p expressions were significantly correlated with the degree ofdifferentiation, tumor, node, metastasis stage, lymph node metastasis, and invasion depth. miR-221-3p and miR-122-5p expression levels were independent prognostic factors forpostoperative gastric cancer. In the diagnosis and predicting prognosis of gastric cancer,receiver operating characteristic analysis revealed that the area under curve of combineddetection of serum miR-221-3p and miR-122-5p expression had a greater diagnostic effectthan either single maker. Conclusions: The miR-221-3p and miR-122-5p are involved in the development of gastriccancer, and they have important clinical values in gastric cancer diagnosis and prognosis.

목차

등록된 정보가 없습니다.

참고문헌 (28)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0