Low Expression of Circulating MicroRNA-34c is Associated with Poor Prognosis in Triple-Negative Breast Cancer

Zhihao Zeng; Xiaowu Chen; Dajian Zhu; Zhongran Luo; Min Yang

doi:10.3349/ymj.2017.58.4.697

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자료유형: 학술저널

저자정보: Zhihao Zeng (Southern Medical University China) Xiaowu Chen (Southern Medical University China) Dajian Zhu (Southern Medical University China) Zhongran Luo (Southern Medical University China) Min Yang (Southern Medical University China)

저널정보: 연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제58권 제4호

발행연도: 2017.7

수록면: 697 - 702 (6page)

DOI: 10.3349/ymj.2017.58.4.697

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Purpose: The microRNA-34 (miR-34) family is important in tumor regulation. This study aimed to investigate the association of circulating miR-34 family proteins with clinicopathological features and their prognostic value in triple-negative breast cancer (TNBC) patients. Materials and Methods: In this cohort study, 173 TNBC patients admitted to First People’s Hospital of Shunde from May 1, 2009 to April 30, 2013 were enrolled. Meanwhile, 75 age-matched healthy women volunteers were identified as healthy controls (HCs). We examined the expression of miR-34 family (miR-34a/b/c) proteins in plasma collected from TNBC patients before any treatmentwas performed and from age-matched HCs using qPCR methods. Results: The expressions of miR-34a/34b/34c were significantly lower in TNBC patients than in HC (p<0.001, p=0.027, p<0.001, respectively). miR-34a was correlated with tumor grade (p=0.038), lymph node positive (p=0.027), distant metastasis (p=0.004), and surgery (p=0.023); miR-34b was correlated with lymph node positivity (p=0.027); and miR-34c was correlated with tumor grade (p=0.017) and distant metastasis (p<0.001). Kaplan-Meier curve analysis displayed low expression of miR-34a as associated with worse overall survival (OS) (p=0.011), as well as miR-34c low expression (p=0.002). In addition, univariate and multivariate Cox proportional hazards regression was performed, and low expression of miR-34c (p=0.011) was found to be an independent risk factor for OS, as well as tumor grade (p=0.013), lymph node positive (p=0.050), and distant metastasis (p=0.021). Conclusion: In conclusion, this study demonstrated reduced miR-34a/c expression is highly associated with tumor progression and indicated worse prognosis. Also, miR-34c was an independent risk factor for OS in TNBC patients.

#Circulating microRNA #triple-negative breast cancer #miR-34 family

참고문헌 (21)

참고문헌 신청

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Perou CM / 2000 / Molecular portraits of human breast tumours / Nature 406:747~752

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Bartel DP / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233

Maroof H / 2014 / MicroRNA-34 family, mechanisms of action in cancer: a review / Curr Cancer Drug Targets 14:737~751

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