지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 55 - 60 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone.
MethodsaaTwenty-five children and adolescents [aged 7–18 years, 12.1±3.3 years (mean±SD); 19 boys and 6 girls] who had been taking risperidone for at least 3 months were enrolled. The following blood parameters were measured: serum levels of prolactin, thyroid hormones, alanine transaminase (ALT), sex hormones, lipids.
ResultsaaThe median risperidone dosage was 1.55 mg/day (SD 1.14 mg/day, range 0.25–4.00 mg/day). The prolactin level (33.65± 16.71 ng/mL, range 5.8–68.3 ng/mL) was higher than normal, and was elevated (≥15 ng/mL in male, ≥23.3 ng/mL in female) in about 84% of the patients. The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001). The TG/HDL ratio was higher in the group with higher prolactin levels (i.e., ≥30 ng/mL), and hence might be a useful marker of insulin resistance.
ConclusionaaIn young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range. Further investigation is needed around this issue. Serum prolactin assessment is recommended for children and adolescents taking risperidone.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alfaro CL / 2002 / Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine / J Child
Ben-Jonathan N / 2006 / Focus on prolactin as a metabolic hormone / Trends Endocrinol Metab 17 : 110 ~ 116
Bushe C / 2008 / A review of the association between antipsychotic use and hyperprolactinaemia / J Psychopharmacol 22 (2 Suppl) : 46 ~ 55
Colao A / 1998 / Growth-hormone and prolactin excess / Lancet 352 : 1455 ~ 1461
Colao A / 2000 / Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization / Clin Endocrinol (Oxf) 52 : 319 ~ 327
Ben-Jonathan N / 2006 / Focus on prolactin as a metabolic hormone / Trends Endocrinol Metab 17 : 110 ~ 116
Bushe C / 2008 / A review of the association between antipsychotic use and hyperprolactinaemia / J Psychopharmacol 22 (2 Suppl) : 46 ~ 55
Colao A / 1998 / Growth-hormone and prolactin excess / Lancet 352 : 1455 ~ 1461
Colao A / 2000 / Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization / Clin Endocrinol (Oxf) 52 : 319 ~ 327
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