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논문 기본 정보

자료유형
학술저널
저자정보
Naganuma Junko (Department of Pediatrics Dokkyo Medical University Shimotsuga Japan) Koyama Satomi (Department of Pediatrics Dokkyo Medical University Shimotsuga Japan) Arisaka Osamu (Dokkyo Medical University Shimotsuga Nasu Red Cross Hospital Otawara Japan) Yoshihara Shigemi (Department of Pediatrics Dokkyo Medical University Shimotsuga Japan)
저널정보
대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제27권 제1호
발행연도
2022.3
수록면
30 - 36 (7page)
DOI
10.6065/apem.2142112.056

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Purpose: We investigated the relationship of 25-hydroxyvitamin D (25[OH]D) level with obesity and atherosclerosis in Japanese adolescents.Methods: We examined 492 children (247 boys and 245 girls) aged 12?13 years. The serum 25(OH)D level was compared among underweight, healthy weight, and overweight children. Spearman correlation coefficient analysis was performed to examine the relationships between the 25(OH)D level and body mass index (BMI), plasma lipids, and blood pressure and to compare the latter between the normal (≥20 ng/mL) and low (<20 ng/mL) 25(OH)D groups. Further, we performed a multiple regression analysis to assess the effect on the 25(OH)D level.Results: The serum 25(OH)D level was significantly lower in overweight (20.5±2.7 ng/mL) than in healthy-weight boys (22.4±3.3 ng/mL) (P=0.004). Spearman correlation coefficients comparing the relationship of the 25(OH)D level with BMI, high-density lipoprotein cholesterol (HDL-C), and atherogenic index indicated significance in boys (ρ=-0.238 [P<0.0001], ρ=0.197 [P=0.002], and ρ=-0.146 [P=0.022], respectively). In boys, the multiple regression analysis results showed that BMI had negative and HDL-C had positive effects on the 25(OH)D level. The first was higher and the latter was lower in boys with low 25(OH)D level than in those with normal levels, respectively (P<0.05). No significant correlations were detected in girls.Conclusion: Low serum 25(OH)D level was associated with obesity and increased atherogenic risk in adolescent boys only. This sex difference was probably mediated by body composition, sun exposure, estrogen, and adiponectin, which are characteristics of puberty.

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