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Reference Intervals for Bone Turnover Markers in Korean Healthy Women
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논문 기본 정보

Type
Academic journal
Author
Journal
The Korean Society of Bone Metabolism 대한골대사학회지 대한골대사학회지 제27권 제1호 KCI Accredited Journals
Published
2020.1
Pages
43 - 52 (10page)

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Reference Intervals for Bone Turnover Markers in Korean Healthy Women
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Background: Adequate suppression of bone turnover rate is important to decrease fracture risk without mineralization defect due to oversuppression. This study was performed to determine reference intervals (RIs) for 2 bone turnover markers, serum C-terminal telopeptide of type I collagen (CTX) and osteocalcin, in Korean women. Methods: A total of 461 Korean women (287 premenopausal and 174 postmenopausal) without any disease or drug history affecting bone metabolism was included. Serum CTX and osteocalcin were measured after overnight fasting. Bone mineral density (BMD) was measured at the 1st to 4th lumbar vertebra using dual energy X-ray absorptiometry. Subjects with normal spinal BMD (T-score ≥-1.0) were included in this study. Results: After stable concentrations were maintained, both CTX and osteocalcin were abruptly increased in 50 to 59 years, and then decreased with increasing age. Median levels and interquartile range of serum CTX and osteocalcin in all subjects were 0.322 (0.212-0.461) ng/mL and 15.68 (11.38-19.91) ng/mL. RIs for serum CTX and osteocalcin in all subjects were 0.115 to 0.861 ng/mL and 6.46 to 36.76 ng/mL. Those were higher in postmenopausal women (CTX, 0.124-1.020 ng/mL, osteocalcin, 5.42-41.57 ng/mL) than in premenopausal women (CTX, 0.101-0.632 ng/mL, osteocalcin, 6.73-24.27 ng/mL). If we use target reference levels as lower half of premenopausal 30 to 45 years in patients with antiresorptive drugs, those were 0.101 to 0.251 ng/mL and 6.40 to 13.36 ng/mL. Conclusions: We established RIs for serum CTX and osteocalcin in healthy Korean women with normal lumbar spine BMD. Premenopausal RIs for serum CTX and osteocalcin would be useful to monitor patients with low bone mass using osteoporosis drugs.

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Garnero P / 1994 / Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment / J Clin Endocrinol Metab 79:1693~1700 google schola Delmas PD / 2000 / Monitoring individual response to hormone replacement therapy with bone markers / Bone 26:553~560 google schola 박소영 / 2019 / Clinical Application of Bone Turnover Markers in Osteoporosis in Korea / 대한골대사학회지 26(1):19~24 google schola 박소영 / 2019 / Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment / 대한골대사학회지 26(4):213~224 dbpia de Papp AE / 2007 / A cross-sectional study of bone turnover markers in healthy premenopausal women / Bone 40:1222~1230 google schola

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