지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 55 - 59 (5page)
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초록· 키워드
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Reliable reference intervals for sex hormones are indispensable in evaluations of the hypothalamo-pituitary-gonadal axis. This study established reference intervals for estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, and prolactin with the immunoassay platforms Advia Centaur and Immulite 2000XP (Siemens Healthcare, Germany). We recruited healthy men (n=220), women in the follicular (n=139) or luteal (n=87) phases of the menstrual cycle, and postmenopausal women (n=103). Data was analyzed according to CLSI EP28-A3c guidelines. Although reference intervals established with both platforms showed good agreement with ranges quoted by the assay manufacturer, two discrepancies were noted. First, intervals for prolactin in women were influenced by hormonal status, and the partition analysis supported their separation into subgroups based on menstrual cycle. Second, the upper limit for estradiol in the follicular phase was nearly a half of that provided by the manufacturer. This discrepancy was attributed to the stringent definition of the follicular phase (consistently set at days 3-5 after menstruation onset). Our findings suggest that reference values for prolactin should both be gender specific and account for menstrual cycle phase. The results also emphasize that clear-cut selection criteria are required when assembling populations for establishing endocrine reference intervals.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Casanueva FF / 2006 / Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas / Clin Endocrinol 65:265~273
Mulders AG / 2003 / Patient predictors for outcome of gonadotrophin ovulation induction in women with normogonadotrophic anovulatory infertility: a meta-analysis / Hum Reprod Update 9:429~449
Bellem A / 2011 / Measuring estrogens and progestagens in humans: an overview of methods / Gend Med 8:283~299
Stanczyk FZ / 2010 / Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies / Cancer Epidemiol Biomarkers Prev 19:903~906
Horowitz GL / 2008 / Defining, establishing and verifying reference intervals in the clinical laboratory; Approved guideline-3rd ed / Clinical Laboratory Standards Institute
Mulders AG / 2003 / Patient predictors for outcome of gonadotrophin ovulation induction in women with normogonadotrophic anovulatory infertility: a meta-analysis / Hum Reprod Update 9:429~449
Bellem A / 2011 / Measuring estrogens and progestagens in humans: an overview of methods / Gend Med 8:283~299
Stanczyk FZ / 2010 / Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies / Cancer Epidemiol Biomarkers Prev 19:903~906
Horowitz GL / 2008 / Defining, establishing and verifying reference intervals in the clinical laboratory; Approved guideline-3rd ed / Clinical Laboratory Standards Institute
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