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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 195 - 204 (10page)
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초록· 키워드
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Background: Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes. Methods: This cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed. Results: Prolactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women. Conclusion: In prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.
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참고문헌 (40)
참고문헌 신청
Tabak AG / 2012 / Prediabetes: a high-risk state for diabetes development / Lancet 379:2279~2290
Forouhi NG / 2007 / Incidence of type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000 / Diabet Med 24:200~207
Horseman ND / 1999 / Prolactin and mammary gland development / J Mammary Gland Biol Neoplasia 4:79~88
Ben-Jonathan N / 1996 / Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects / Endocr Rev 17:639~669
Freeman ME / 2000 / Prolactin: structure, function, and regulation of secretion / Physiol Rev 80:1523~1631
Forouhi NG / 2007 / Incidence of type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000 / Diabet Med 24:200~207
Horseman ND / 1999 / Prolactin and mammary gland development / J Mammary Gland Biol Neoplasia 4:79~88
Ben-Jonathan N / 1996 / Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects / Endocr Rev 17:639~669
Freeman ME / 2000 / Prolactin: structure, function, and regulation of secretion / Physiol Rev 80:1523~1631
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