지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 400 - 406 (7page)
이용수
초록· 키워드
오류제보하기
Cancer/testis (CT) antigens exhibit highly tissue-restricted expression and are considered promising targets for cancer vaccines. Here we identified a novel CT gene ZNF645 which restrictively expresses in normal human testes and lung cancer patients (68.3%). To investigate the promoter methylation status of ZNF645, we carried out bisulfite genomic sequencing and found that the CpG island in its promoter was heavily methylated in normal lung tissues without the expression of ZNF645, whereas there was high demethylation in normal human testes and lung carcinoma tissues with its expression.
Also ZNF645 could be remarkably activated in A549 and HEK293T cells treated by DNA demethylation agent 5'-aza-2'-deoxycytidine. And the dual luciferase assay revealed that the promoter activity of the ZNF645 was inhibited by methylation of the CpG island region. Therefore, we proposed that ZNF645is a CT gene and activated in human testis and lung cancers by demethylation of its promoter region.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Antequera, F. / 1993 / CpG islands / EXS. 64 : 169 ~ 185
Antequera, F. / 1993 / Number of CpG islands and genes in human and mouse / Proc. Natl. Acad. Sci. U.S.A. : 11995 ~ 11999
Bird, A. / 1999 / Methylation-induced repression--belts, braces, and chromatin / Cell. 99 : 451 ~ 454
Bird, A. / 2002 / DNA methylation patterns and epigenetic memory / Genes. Dev. 16 : 6 ~ 21
Cedar, H. / 1988 / DNA methylation and gene activity / Cell. 53 : 3 ~ 4
Antequera, F. / 1993 / Number of CpG islands and genes in human and mouse / Proc. Natl. Acad. Sci. U.S.A. : 11995 ~ 11999
Bird, A. / 1999 / Methylation-induced repression--belts, braces, and chromatin / Cell. 99 : 451 ~ 454
Bird, A. / 2002 / DNA methylation patterns and epigenetic memory / Genes. Dev. 16 : 6 ~ 21
Cedar, H. / 1988 / DNA methylation and gene activity / Cell. 53 : 3 ~ 4
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer
BMB Reports
2017 .01
-
ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity
BMB Reports
2010 .01
-
ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway
BMB Reports
2010 .01
-
A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway
BMB Reports
2011 .01
-
Znf45l affects primitive hematopoiesis by regulating transforming growth factor-β signaling
BMB Reports
2014 .01
-
공기 중에서 열증발법에 의하여 제작된 정팔면체 ZnO 결정
전기전자재료학회논문지
2013 .01
-
Demethylation of CpG islands in the 5' upstream regions mediates the expression of the human testis-specific gene MAGEB16 and its mouse homolog Mageb16
BMB Reports
2014 .01
-
유전자 알고리즘을 이용한 Promoter 예측
한국정보과학회 학술발표논문집
1999 .10
-
Promoter-Selection Vector를 사용한 유산균 Promoter의 탐색
KSBB Journal
1996 .08
-
Effect of CMV Promoter Methylation on Gene Transcription in CHO Cells
한국생물공학회 학술대회
2011 .04
-
Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4
BMB Reports
2018 .01
-
ZnO:F films by magnetron sputter-deposition: A comparison of fluorine sources between $ZnF_2$ containing targets and CF4 containing gas mixtures
한국재료학회 학술발표대회
2007 .01
-
Epigenetic modification of retinoic acid-treated human embryonic stem cells
BMB Reports
2010 .01
-
CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7
BMB Reports
2013 .01
-
난류촉진체에 의한 장방형덕트내의 발열블럭으로부터의 강제대류 열전달 촉진
대한설비공학회 학술발표대회논문집
1995 .11
-
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells
BMB Reports
2011 .01
-
Genomic Approaches for Cloning Promoters and Its Applications
한국생물공학회 학술대회
2014 .04
-
바이오메디컬 데이터 처리를 위한 데이터마이닝 활용
전기학회논문지
2016 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0