지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 58 - 63 (6page)
이용수
초록· 키워드
오류제보하기
Zinc finger (ZNF) proteins play a critical role in cell growth,proliferation, apoptosis, and intracellular signal transduction.
In this paper, we cloned and characterized a novel human KRAB-related zinc finger gene, ZNF425, which encodes a protein of 752 amino acids. ZNF425 is strongly expressed in the three month old human embryos and then is almost undetectable in six month old embryos and in adult tissues. An EGFP-ZNF425 fusion protein can be found in both the nucleus and the cytoplasm. ZNF425 appears to act as a transcription repressor. Over-expression of ZNF425 inhibits the transcriptional activities of SRE, AP-1, and SRF. Deletion analysis indicates that the C2H2 domain is the main region responsible for the repression. Our results suggest that the ZNF425 gene is a new transcriptional inhibitor that functions in the MAPK signaling pathway. [BMB reports 2011; 44(1): 58-63]
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bellefroid, E. J / 1991 / The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins / Proc. Natl. Acad. Sci. U.S.A
Brayer, K. J / 2008 / Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains / Cell Biochem. Biophys 50 : 111 ~ 131
Cao, L / 2005 / ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway / Biochem. Biophys. Res. Commun 333 : 1050 ~ 1059
Chang, L / 2001 / Mammalian MAP kinase signaling cascades / Nature 410 : 37 ~ 40
Cheng, Y / 2010 / The KRAB Zinc finger protein ZNF382 is a general, pro-apoptotic tumor suppressor repressing multiple oncogenes and frequently silenced by CpG methylation i
Brayer, K. J / 2008 / Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains / Cell Biochem. Biophys 50 : 111 ~ 131
Cao, L / 2005 / ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway / Biochem. Biophys. Res. Commun 333 : 1050 ~ 1059
Chang, L / 2001 / Mammalian MAP kinase signaling cascades / Nature 410 : 37 ~ 40
Cheng, Y / 2010 / The KRAB Zinc finger protein ZNF382 is a general, pro-apoptotic tumor suppressor repressing multiple oncogenes and frequently silenced by CpG methylation i
이 논문의 저자 정보
최근 본 자료
댓글(0)
0