지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 830 - 835 (6page)
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초록· 키워드
오류제보하기
Epigenetic modification of the genome through DNA methylation is the key to maintaining the differentiated state of human embryonic stem cells (hESCs), and it must be reset during differentiation by retinoic acid (RA) treatment. A genome-wide methylation/gene expression assay was performed in order to identify epigenetic modifications of RA-treated hESCs. Between undifferentiated and RA-treated hESCs, 166 differentially methylated CpG sites and 2,013 differentially expressed genes were discovered. Combined analysis of methylation and expression data revealed that 19 genes (STAP2, VAMP8, C10orf26,WFIKKN1, ELF3, C1QTNF6, C10orf10, MRGPRF, ARSE, LSAMP,CENTD3, LDB2, POU5F1, GSPT2, THY1, ZNF574, MSX1,SCMH1, and RARB) were highly correlated with each other.
The results provided in this study will facilitate future investigations into the interplay between DNA methylation and gene expression through further functional and biological studies.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abeyta, M. J. / 2004 / Bodnar, M. S., Pera, R. A. and Firpo, M. T. (2004) Unique gene expression / Hum. Mol. Genet. 13 : 601 ~ 608
Adewumi, O. / 2007 / Characterization of human embryonic stem cell lines by the International Stem Cell Initiative / Nat. Biotechnol. 25 : 803 ~ 816
Andrews, P. W. / 2005 / The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research / Nat. Biotechnol. 23 : 795 ~ 797
Bibikova, M. / 2006 / Human embryonic stem cells have a unique epigenetic signature / Genome Res. 16 : 1075 ~ 1083
Brunner, A. L. / 2009 / Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver / Genome Res. 19 : 1044 ~ 1
Adewumi, O. / 2007 / Characterization of human embryonic stem cell lines by the International Stem Cell Initiative / Nat. Biotechnol. 25 : 803 ~ 816
Andrews, P. W. / 2005 / The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research / Nat. Biotechnol. 23 : 795 ~ 797
Bibikova, M. / 2006 / Human embryonic stem cells have a unique epigenetic signature / Genome Res. 16 : 1075 ~ 1083
Brunner, A. L. / 2009 / Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver / Genome Res. 19 : 1044 ~ 1
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