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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 448 - 453 (6page)
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CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not yet been defined. Therefore, we investigated the effects of CpG-DNA on the expression of costimulatory molecules in RAW 264.7 cells. The surface expression of CD80 was slightly increased and CD83expression was significantly increased in response to CpG-DNA. However, the expression of CD86 and MHC class II was not changed. As expression of CD83 mRNA was also increased by CpG-DNA, CD83 expression is regulated at a transcriptional level. To understand the contribution of signaling pathways to CD83 induction, we used pathway specific inhibitors. The NF-κB inhibitor significantly reduced surface expression of CD83 as well as phagocytic activity of RAW 264.7 cells. Therefore, CD83 expression may contribute to the immunostimulatory effects of CpG-DNA in macrophage cells. [BMB Reports 2013; 46(9): 448-453]
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참고문헌 (25)
참고문헌 신청
Aderem, A. / 2000 / Toll-like receptors in the induction of the innate immune response / Nature 406 : 782 ~ 787
Akira, S. / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Anderson, K. V. / 2000 / Toll signaling pathways in the innate immune response / Curr. Opin. Immunol 12 : 13 ~ 19
Breloer, M. / 2007 / CD83 is a regulator of murine B cell function in vivo / Eur. J. Immunol 37 : 634 ~ 648
Caux, C. / 1994 / Activation of human dendritic cells through CD40 cross-linking / J. Exp. Med 180 : 1263 ~ 1272
Akira, S. / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Anderson, K. V. / 2000 / Toll signaling pathways in the innate immune response / Curr. Opin. Immunol 12 : 13 ~ 19
Breloer, M. / 2007 / CD83 is a regulator of murine B cell function in vivo / Eur. J. Immunol 37 : 634 ~ 648
Caux, C. / 1994 / Activation of human dendritic cells through CD40 cross-linking / J. Exp. Med 180 : 1263 ~ 1272
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