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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 242 - 248 (7page)
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Induced pluripotent stem cells (iPSCs) show great promise for replacing current stem cell therapies in the field of regenerative medicine. However, the original method for cellular reprogramming, involving four exogenous transcription factors, is characterized by low efficiency. Here, we focused on using epigenetic modifications to enhance the reprogramming efficiency. We hypothesized that there would be a new reprogramming factor involved in DNA demethylation, acting on the promoters of pluripotency-related genes. We screened proteins that bind to the methylated promoter of Oct4 and identified Zinc finger protein 127 (Zfp127), the functions of which have not yet been identified. We found that Zfp127 binds to the Oct4 promoter. Overexpression of Zfp127 in fibroblasts induced demethylation of the Oct4 promoter, thus enhancing Oct4 promoter activity and gene expression. These results demonstrate that Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming.
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참고문헌 (30)
참고문헌 신청
Takahashi K / 2006 / Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors / Cell 126:663~676
Okita K / 2008 / Generation of mouse induced pluripotent stem cells without viral vectors / Science 322:949~953
Zhou W / 2009 / Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells / Stem Cells 27:2667~2674
Miyoshi N / 2011 / Reprogramming of mouse and human cells to pluripotency using mature microRNAs / Cell Stem Cell 8:633~638
Xu N / 2009 / MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells / Cell 137:647~658
Okita K / 2008 / Generation of mouse induced pluripotent stem cells without viral vectors / Science 322:949~953
Zhou W / 2009 / Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells / Stem Cells 27:2667~2674
Miyoshi N / 2011 / Reprogramming of mouse and human cells to pluripotency using mature microRNAs / Cell Stem Cell 8:633~638
Xu N / 2009 / MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells / Cell 137:647~658
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