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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 621 - 627 (7page)
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오류제보하기
We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer. Immunohistochemistry was used to determine the expression of ZNF143 in normal tissues and in tissues from metastatic breast cancer at various stages. Notably, ZNF143 was selectively expressed in duct and gland epithelium of normal breast tissues, which decreased when the tissue became malignant. To determine the molecular mechanism how ZNF143 affects breast cancer progression, it was knocked down by infecting benign breast cancer cells with shorthairpin (sh) RNA-lentiviral particles against ZNF143 (MCF7 sh-ZNF143). MCF7 sh-ZNF143 cells showed different cell-cell contacts and actin filament (F-actin) structures when compared with MCF7 sh-Control cells. In migration and invasion assays, ZNF143 knockdown induced increased cellular motility in breast carcinoma cells. This was reduced by the recovery of ZNF143 expression. Taken together, these results suggest that ZNF143 expression contributes to breast cancer progression.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bailey SD / 2015 / ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters / Nat Commun 2 : 6186 ~
Cancer Genome Atlas N / 2012 / Comprehensive molecular portraits of human breast tumours / Nature 490 : 61 ~ 70
Ciriello G / 2015 / Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer / Cell 163 : 506 ~ 519
Gatza ML / 2014 / An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer / Nat Genet 46 : 1051 ~ 1059
Halbig KM / 2012 / The transcriptional activator ZNF143 is essential for normal development in zebrafish / BMC Mol Biol 13 : 3 ~
Cancer Genome Atlas N / 2012 / Comprehensive molecular portraits of human breast tumours / Nature 490 : 61 ~ 70
Ciriello G / 2015 / Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer / Cell 163 : 506 ~ 519
Gatza ML / 2014 / An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer / Nat Genet 46 : 1051 ~ 1059
Halbig KM / 2012 / The transcriptional activator ZNF143 is essential for normal development in zebrafish / BMC Mol Biol 13 : 3 ~
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