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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 212 - 218 (7page)
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초록· 키워드
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Zinc finger-containing transcription factors are the largest single family of transcriptional regulators in mammals, which play an essential role in cell differentiation, cell proliferation,apoptosis, and neoplastic transformation. Here we have cloned a novel KRAB-related zinc finger gene, ZNF424, encoding a protein of 555aa. ZNF424 gene consisted of 4 exons and 3 introns,and mapped to chromosome 19p13.3. ZNF424 gene was ubiquitously expressed in human embryo tissues by Northern blot analysis. ZNF424 is conserved across species in evolution. Using a GFP-labeled ZNF424 protein, we demonstrate that ZNF424 localizes mostly in the nucleus. Transcriptional activity assays shows ZNF424 suppresses transcriptional activity of L8G5-luciferase. Overexpression of ZNF424 in HEK-293 cells inhibited the transcriptional activity of NFAT and p21, which may be silenced by siRNA. The results suggest that ZNF424 protein may act as a transcriptional repressor that suppresses NFAT and p21 pathway to mediate cellular functions.
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참고문헌 (22)
참고문헌 신청
Bellefroid, E. J. / 1991 / The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins / Proc. Natl. Acad. Sci. U.S.A. : 360
Friedman, J. R. / 1996 / KAP-1, a novel corepressor for the highly conserved KRAB repression domain / Genes Dev. 10 : 2067 ~ 2078
Gebelein, B. / 2001 / Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppelassociated box protein / Mol. Cell Biol. 21 : 928 ~ 939
Huntley, S. / 2006 / A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressor
Jae-Hwan Kim / 2008 / Minimizing a QTL region for intramuscular fat content bycharacterizing the porcine Phosphodiesterase 4B (PDE4B) gene / BMB reports 41 (6) : 466 ~ 471
Friedman, J. R. / 1996 / KAP-1, a novel corepressor for the highly conserved KRAB repression domain / Genes Dev. 10 : 2067 ~ 2078
Gebelein, B. / 2001 / Sequence-specific transcriptional repression by KS1, a multiple-zinc-finger-Kruppelassociated box protein / Mol. Cell Biol. 21 : 928 ~ 939
Huntley, S. / 2006 / A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressor
Jae-Hwan Kim / 2008 / Minimizing a QTL region for intramuscular fat content bycharacterizing the porcine Phosphodiesterase 4B (PDE4B) gene / BMB reports 41 (6) : 466 ~ 471
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