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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 193 - 198 (6page)
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In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB domain and seven carboxyl-terminal C2H2 zinc finger motifs in the nucleus and cytoplasm. Northern blotting analysis indicated that a 2.3 kb transcript specific for ZNF552 was expressed in liver, lung, spleen, testis and kidney,especially with a higher level in the lung and testis in human adult tissues. Reporter gene assays showed that ZNF552 was a transcriptional repressor, and overexpression of ZNF552 in the COS-7 cells inhibited the transcriptional activities of AP-1 and SRE, which could be relieved through RNAi analysis. Deletion studies showed that the KRAB domain of ZNF552 may be involved in this inhibition.
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참고문헌 (22)
참고문헌 신청
Agata, Y. / 1999 / Two novel Kruppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepress
Cai, Z. Y. / 2006 / hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum reponse factor / Bioc
Dang, D. T. / 2000 / The biology of the mammalian Kruppel-like family of transcription factors / Int. J. Biochem. Cell. Biol. 32 : 1103 ~ 1121
Friedman, J. R. / 1996 / KAP-1 a novel corepressor for the highly conserved KRAB repression domain / Genes. Dev. 10 : 2067 ~ 2078
Gou, D. M. / 2004 / Identification and functional analysis of a novel human KRAB/C zinc finger gene ZNF300 / Biochim. Biophys. Acta. 1676 : 203 ~ 209
Cai, Z. Y. / 2006 / hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum reponse factor / Bioc
Dang, D. T. / 2000 / The biology of the mammalian Kruppel-like family of transcription factors / Int. J. Biochem. Cell. Biol. 32 : 1103 ~ 1121
Friedman, J. R. / 1996 / KAP-1 a novel corepressor for the highly conserved KRAB repression domain / Genes. Dev. 10 : 2067 ~ 2078
Gou, D. M. / 2004 / Identification and functional analysis of a novel human KRAB/C zinc finger gene ZNF300 / Biochim. Biophys. Acta. 1676 : 203 ~ 209
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