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논문 기본 정보

자료유형
학술저널
저자정보
Lee Won (Department of Brain and Cognitive Sciences Seoul National University College of Natural Sciences Seoul Republic of Korea) Park Hyungyou (Department of Brain and Cognitive Sciences Seoul National University College of Natural Sciences Seoul Republic of Korea) Moon Sun-Young (Department of Psychiatry Hallym University Kangnam Sacred Heart Medical Center Seoul Republic of Korea) Oh Sanghoon (Department of Psychiatry Eulji University Uijeongbu Eulji Medical Center Uijeongbu Republic of Korea) Lee Junhee (Department of Psychiatry Eulji University Uijeongbu Eulji Medical Center Uijeongbu Republic of Korea) Kim Minah (Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea) Kwon Jun Soo (Department of Brain and Cognitive Sciences Seoul National University College of Natural Sciences Seoul Republic of Korea)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제20권 제6호
발행연도
2023.6
수록면
550 - 558 (9page)
DOI
10.30773/pi.2022.0334

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Objective The cerebello-thalamic tract is the only efferent white matter (WM) bundle of the cerebellum that connects the cerebellum to the thalamus and has recently attracted much attention in obsessive-compulsive disorder (OCD) with its integral role in higher order cognitive functions commonly impaired in OCD patients. Previous neuroimaging studies have shown that the cerebello-thalamic circuit is functionally impaired in OCD patients. However, the WM integrity of the cerebello-thalamic tract in OCD, which may underly functional abnormalities of the cerebello-thalamic circuit, is not yet sufficiently understood. Therefore, the current study aimed to elucidate whether compromised cerebello-thalamic WM integrity is observed in medication-free OCD patients.Methods In this study, diffusion tensor imaging was acquired from 106 medication-free OCD patients and 105 matched healthy controls (HCs). Probabilistic tractography was then used to reconstruct the cerebello-thalamic tract with accurate anatomical features. Three diffusion indices (fractional anisotropy, FA; mean diffusivity, MD; radial diffusivity, RD) were measured from the reconstructed bilateral cerebello-thalamic tract and then compared between groups.Results We found that patients with OCD showed significantly increased MD and RD in the right cerebello-thalamic tract compared to HCs, and there was no difference in FA between groups.Conclusion Our findings may indicate the underlying structural abnormalities of the dysfunctional cerebello-thalamic circuit in OCD patients. Therefore, our findings are expected to provide novel insights into the pathophysiology of OCD on the cerebello-thalamic WM architecture, extending our knowledge from the existing functional neurobiological model of OCD.

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