지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : Impaired response inhibition has been suggested to play an important role in the pathophysi- ology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibi- tion in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with com- mission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contrib- ute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in pa- tients with OCD. (Anxiety and Mood 2015;11(1):33-37)
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ting JT / 2011 / Neurobiology of obsessive-compulsive disorder : insights into neural circuitry dysfunction through mouse genetics / Curr Opin Neurobiol 21:842~848
Menzies L / 2008 / Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder : the orbitofronto-striatal model revisited / Neurosci Biobehav Rev 32:525~549
Chamberlain SR / 2008 / Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives / Science 321:421~422
Ahmari SE / 2013 / Repeated cortico-striatal stimulation generates persistent OCD-like behavior / Science 340:1234~1239
Bari A / 2013 / Inhibition and impulsivity : behavioral and neural basis of response control / Prog Neurobiol 108:44~79
Menzies L / 2008 / Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder : the orbitofronto-striatal model revisited / Neurosci Biobehav Rev 32:525~549
Chamberlain SR / 2008 / Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives / Science 321:421~422
Ahmari SE / 2013 / Repeated cortico-striatal stimulation generates persistent OCD-like behavior / Science 340:1234~1239
Bari A / 2013 / Inhibition and impulsivity : behavioral and neural basis of response control / Prog Neurobiol 108:44~79
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