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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 87 - 95 (9page)
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초록· 키워드
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Objective It is well established that the cortico-striato-thalamo-cortical (CSTC) circuit is implicated in the pathophysiology of obsessive- compulsive disorder (OCD). However, reports on corticostriatal functional connectivity (FC) in OCD have been inconsistent due to the structural and functional heterogeneity of the striatum. Therefore, in the present study, we investigated corticostriatal FC using a fine 12-seed striatal parcellation to overcome this heterogeneity and discover the neural correlates of symptoms in OCD patients. Methods We recruited 23 OCD patients and 23 healthy controls (HCs). Whole-brain FC based on striatal seeds was examined using resting-state functional magnetic resonance imaging data and compared across OCD patients and HCs. We conducted correlation analysis between FCs of striatal subregions with significant group differences and symptom severity scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Rating Scale for Depression, and Hamilton Rating Scale for Anxiety (HAM-A). Results Compared to HCs, patients demonstrated increased FC of the dorsal caudal putamen and ventral rostral putamen (VRP) with several cortical regions, such as the intracalcarine cortex, inferior frontal gyrus, supramarginal/angular gyrus (SMG/AG), and postcentral gyrus (PCG). Furthermore, FC between the VRP and SMG/AG and between the VRP and PCG was negatively correlated with scores on the Y-BOCS compulsive subscale and the HAM-A, respectively. Conclusion These findings suggest that striatal subregions have strengthened FC with extensive cortical regions, which may reflect neural correlates of compulsive and anxious symptoms in OCD patients. These results contribute to an improved understanding of OCD pathophysiology by complementing the current evidence regarding striatal FC.
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참고문헌 (6)
참고문헌 신청
Harrison BJ / 2009 / Altered corticostriatal functional connectivity in obsessive-compulsive disorder / Arch Gen Psychiatry 66:1189~1200
Sakai Y / 2011 / Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder / Eur Psychiatry 26:463~469
Harrison BJ / 2013 / Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder / Biol Psychiatry 73:321~328
Posner J / 2014 / Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder / Hum Brain Mapp 35:2852~2860
Chen Y / 2016 / Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder / Neurosci Lett 623:57~62
Sakai Y / 2011 / Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder / Eur Psychiatry 26:463~469
Harrison BJ / 2013 / Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder / Biol Psychiatry 73:321~328
Posner J / 2014 / Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder / Hum Brain Mapp 35:2852~2860
Chen Y / 2016 / Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder / Neurosci Lett 623:57~62
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