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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Bottas A / 2005 / Comorbidity and pathophysiology of obsessive-compulsive disorder in schizophrenia: is there evidence for a schizo-obsessive subtype of schizophrenia? / J Psychiatry Neurosci 30:187~193
Kim MS / 2003 / Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder / Psychiatry Res 123:109~123
Kwon JS / 2003 / Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex / J Neurol Neurosurg Psychiatry 74:962~964
Tumkaya S / 2009 / Schizophrenia with obsessive-compulsive disorder and obsessive-compulsive disorder with poor insight: a neuropsychological comparison / Psychiatry Res 165:38~46
Roh KS / 2005 / Persistent cognitive dysfunction in patients with obsessive-compulsive disorder:a naturalistic study / Psychiatry Clin Neurosci 59:539~545
Kim MS / 2003 / Neuropsychological correlates of P300 abnormalities in patients with schizophrenia and obsessive-compulsive disorder / Psychiatry Res 123:109~123
Kwon JS / 2003 / Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex / J Neurol Neurosurg Psychiatry 74:962~964
Tumkaya S / 2009 / Schizophrenia with obsessive-compulsive disorder and obsessive-compulsive disorder with poor insight: a neuropsychological comparison / Psychiatry Res 165:38~46
Roh KS / 2005 / Persistent cognitive dysfunction in patients with obsessive-compulsive disorder:a naturalistic study / Psychiatry Clin Neurosci 59:539~545
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