지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 777 - 785 (9page)
이용수
초록· 키워드
오류제보하기
Objective This study assessed the associations of the abnormal brain activation and functional connectivity (FC) during memory processing and brain volume alteration in conjunction with psychiatric symptom severity in patients with obsessive-compulsive disorder (OCD).Methods Twenty-OCD patients and 20-healthy controls (HC) underwent T1-weighted and functional imaging underlying explicit memory task.Results In memory encoding, OCD patients showed higher activities in right/left (Rt./Lt.) inferior temporal gyrus (ITG), medial prefrontal cortex (MPFC), dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC), compared with HC. In task-based FC, caudate (Cd) was positively connected with DLPFC and ITG in OCD, while HC showed different connectivities of Cd-ACC and Rt.-Lt. ITG. In memory retrieval, only Cd was activated in OCD patients. Cd was positively connected with DLPFC and vmPFC in OCD, but negatively connected between same brain areas in HC. OCD patients showed increased gray matter (GM) volumes of cerebellum, DLPFC, orbitofrontal cortex (OFC), hippocampus, Cd and ITG, and concurrently, increased white matter volumes of DLPFC. In OCD patients, GM volumes of Cd and OFC were positively correlated with HAMA and Y-BOCS. Functional activity changes of Cd in OCD were positively correlated with Y-BOCS.Conclusion Our findings support to accessing clinical symptom and its severity linked by brain structural deformation and functional abnormality in OCD patients.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Goodman WK / 2014 / Obsessive-compulsive disorder / Psychiatr Clin North Am 37:257~267
Leman İnanç / 2018 / Are Mentalizing Abilities and Insight Related to the Severity of Obsessive-Compulsive Disorder / PSYCHIATRY INVESTIGATION 15(9):843~851
Nakao T / 2009 / Working memory dysfunction in obsessive-compulsive disorder : a neuropsychological and functional MRI study / J Psychiatr Res 43:784~791
van den Heuvel OA / 2005 / Frontal-striatal dysfunction during planning in obsessive-compulsive disorder / Arch Gen Psychiatry 62:301~309
Deckersbach T / 2000 / The relationship between semantic organization and memory in obsessive-compulsive disorder / Psychother Psychosom 69:101~107
Leman İnanç / 2018 / Are Mentalizing Abilities and Insight Related to the Severity of Obsessive-Compulsive Disorder / PSYCHIATRY INVESTIGATION 15(9):843~851
Nakao T / 2009 / Working memory dysfunction in obsessive-compulsive disorder : a neuropsychological and functional MRI study / J Psychiatr Res 43:784~791
van den Heuvel OA / 2005 / Frontal-striatal dysfunction during planning in obsessive-compulsive disorder / Arch Gen Psychiatry 62:301~309
Deckersbach T / 2000 / The relationship between semantic organization and memory in obsessive-compulsive disorder / Psychother Psychosom 69:101~107
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
Executive Dysfunction in Obsessive-Compulsive Disorder and Anterior Cingulate-Based Resting State Functional Connectivity
PSYCHIATRY INVESTIGATION
2017 .01
-
Personality Beliefs in Obsessive-Compulsive Disorder: How Are They Related to Symptom Severity?
PSYCHIATRY INVESTIGATION
2020 .01
-
안정화된 만성 조현병 환자에서 강박장애 증상이 삶의 질에 미치는 영향
대한불안의학회지
2017 .01
-
강박장애에 대한 경두개 직류자극술의 적용
대한불안의학회지
2021 .01
-
국내 일대학병원에서 강박장애 집단 기반 수용전념치료의 효과 검증
생물치료정신의학
2022 .02
-
Adjunctive Low-frequency Repetitive Transcranial Magnetic Stimulation over the Right Dorsolateral Prefrontal Cortex in Patients with Treatment-resistant Obsessive-compulsive Disorder: A Randomized Controlled Trial
Clinical Psychopharmacology and Neuroscience
2016 .01
-
강박장애 환자의 반응억제 결함
대한불안의학회지
2015 .04
-
New Onset Obsessive Compulsive Disorder Following High Frequency Repetitive Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex for Treatment of Negative Symptoms in a Patient with Schizophrenia
Clinical Psychopharmacology and Neuroscience
2019 .01
-
강박장애 및 조현병 환자에서의 정량뇌파 소견과 신경인지기능 간의 연관성
생물정신의학
2016 .01
-
강박장애 환자에서 체험회피, 인지융합 및 강박증상 간의 관계
대한불안의학회지
2021 .01
-
Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder in Korea
PSYCHIATRY INVESTIGATION
2016 .01
-
Informational Analysis and Prediction of Obsessive-Compulsive Disorder Pathogenesis
PSYCHIATRY INVESTIGATION
2024 .05
-
Reconciliation of Two Cognitive Models in Obsessive-Compulsive Disorder: An fMRI Study
PSYCHIATRY INVESTIGATION
2021 .01
-
Evaluation of Relationship between Obsessive-compulsive Disorder and Dissociative Experiences
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Compromised Cerebello-Thalamic White Matter Integrity in Medication-Free Patients With Obsessive-Compulsive Disorder
PSYCHIATRY INVESTIGATION
2023 .06
-
Examining the Psychometric Properties and Clinical Correlates of the Korean Version of the Family Accommodation Scale-Self-Rated Version for Obsessive-Compulsive Disorder
PSYCHIATRY INVESTIGATION
2022 .03
-
강박장애의 Acceptance and Commitment Therapy
대한소아청소년정신의학회 학술대회논문집
2023 .05
-
Characteristics of Patients With Intractable Obsessive-Compulsive Disorder With High/Low Responsiveness to Gamma Knife Surgery
PSYCHIATRY INVESTIGATION
2024 .06
-
The Potential Usefulness of Magnetic Resonance Guided Focused Ultrasound for Obsessive Compulsive Disorders
대한신경외과학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0