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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 504 - 510 (7page)
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초록· 키워드
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ObjectiveaaThis study aimed to investigate thalamic shape alterations and their relationships with various episodic memory impairments in subjects with amnestic mild cognitive impairment (aMCI).
MethodsaaWe compared volumes and morphological alterations of the thalamus between aMCI subjects and healthy controls. In addition, we investigated the correlation between thalamic deformations and various memory impairments in aMCI subjects using a comprehensive neuropsychological battery.
ResultsaaThe normalized left thalamic volumes of the aMCI group were significantly smaller than those of the healthy control group (p<0.0001). aMCI subjects exhibited significant thalamic deformations in the left thalamic dorso-medial and antero-medial areas compared with healthy individuals. CERAD-K Word List Memory scores were significantly correlated with the left dorso-medial areas in aMCI subjects. There were no significant correlations between verbal fluency, Boston naming test, constructional praxis, Word List Recognition, and Visuospatial Recall scores and thalamic shape in aMCI subjects. Verbal delayed recall scores were also significantly correlated with the left dorso-medial areas in the aMCI group.
ConclusionaaStructural alterations in the thalamic deformations in the left dorso-medial and antero-medial areas might be core underlying neurobiological mechanisms of thalamic dysfunction related to Word List Memory and delayed verbal recall in individuals with aMCI.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Inter Med 256:183~194
Petersen RC / 2001 / Current concepts in mild cognitive impairment / Arch Neurol 58:1985~1992
Clark DL / 2010 / The Brain and Behavior: An Introduction to Behavioral Neuroanatomy / Cambridge University Press
Pedro T / 2012 / Volumetric brain changes in thalamus, corpus callosum and medial temporal structures: mild Alzheimer’s disease compared with amnestic mild cognitive impairment / Dement Geriatr Cogn Disord 34:149~155
Stepan-Buksakowska I / 2014 / Cortical and subcortical atrophy in Alzheimer disease : parallel atrophy of thalamus and hippocampus / Alzheimer Dis Assoc Disord 28:65~72
Petersen RC / 2001 / Current concepts in mild cognitive impairment / Arch Neurol 58:1985~1992
Clark DL / 2010 / The Brain and Behavior: An Introduction to Behavioral Neuroanatomy / Cambridge University Press
Pedro T / 2012 / Volumetric brain changes in thalamus, corpus callosum and medial temporal structures: mild Alzheimer’s disease compared with amnestic mild cognitive impairment / Dement Geriatr Cogn Disord 34:149~155
Stepan-Buksakowska I / 2014 / Cortical and subcortical atrophy in Alzheimer disease : parallel atrophy of thalamus and hippocampus / Alzheimer Dis Assoc Disord 28:65~72
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