지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.1
- 수록면
- 39 - 47 (9page)
- DOI
- 10.1007/s13258-022-01327-9
이용수
초록· 키워드
오류제보하기
Background Substantial evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), play a vital role in human cancer. Phosphoserine aminotransferase 1 (PSAT1) is a serine biosynthesis-related member of the aminotransferase family and is closely associated with worse prognosis in triple-negative breast cancer (TNBC).
Objective The present study elucidated the molecular mechanisms underlying PSAT1 regulation by miRNAs in TNBC.
Methods After collecting breast cancer and para-cancerous tissues, expression and functional testing of microRNA-195-5p (miR-195-5p) and PSAT1 were implemented both in vivo and in vitro.
Results Abnormally low miR-195-5p expression was confirmed in TNBC tissues and cells. The specific targeting effect of miR-195-5p on PSAT1 was screened. Our observations revealed that biological tumor behavior was inhibited after miR-195-5p upregulation and this inhibition could be reversed by PSAT1 overexpression both in vivo and in vitro.
Conclusion Our study revealed the regulatory axis of miR-195-5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA‑125a‑5p and miRNA‑181a‑5p
Genes & Genomics
2019 .01
-
Circulating microRNA expression profiling in young obese Korean women
Nutrition Research and Practice
2020 .08
-
Circulating microRNA expression profiling in young obese Korean women
Nutrition Research and Practice
2020 .08
-
miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs
Molecules and Cells
2016 .04
-
Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4
Genes & Genomics
2022 .05
-
Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer
Genomics & informatics
2015 .01
-
Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes
Genes & Genomics
2018 .01
-
miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro
Molecules and Cells
2018 .03
-
MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6
Genes & Genomics
2022 .02
-
The seed sequence is necessary but insufficient for downregulation of target genes by miR-608
Genes & Genomics
2016 .01
-
The MicroRNA-551a/MEF2C Axis Regulates the Survival and Sphere Formation of Cancer Cells in Response to 5-Fluorouracil
Molecules and Cells
2019 .01
-
High throughput sequencing of herbaceous peony small RNAs to screen thermo-tolerance related microRNAs
Genes & Genomics
2017 .01
-
폐암에서 microRNA 155의 발현 양상과 임상병리학적 의의
생명과학회지
2016 .09
-
Comparison of the miR-23b and miR-203 Expressions in Endometrial Cancer
대한임상검사과학회지
2017 .01
-
MicroRNA sequencing detects miR-424-5p up-regulation in ovarian cancer stem cells
Genes & Genomics
2015 .01
-
Roles of miR-128 in Myogenic Differentiation and Insulin Signaling in Rat L6 Myoblasts
생명과학회지
2020 .09
-
A study to find a new specific target for triple-negative breast cancer therapy
한국분석과학회 학술대회
2022 .11
-
In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein
Genomics & informatics
2016 .01
-
다발성골수종 환자의 파라핀포매조직에서 MicroRNA 발현
대한임상검사과학회지
2015 .01
-
Hsa_Circ_0001947/MiR-661/DOK7 Axis Restrains Non-Small Cell Lung Cancer Development
Journal of Microbiology and Biotechnology
2021 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0