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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 292 - 297 (6page)
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Research of thyroid cancer, liver cancer, and lung cancer has been reported in Korea. However microRNA research of multiple myeloma has never been reported. Hence we intended to confirm whether microRNA can be utilized as a diagnostic marker to patients of multiple myeloma. We also intended to evaluate whether microRNA can be detected in paraffin-embedded tissue (FFPE). This research was conducted targeting 8 samples from patients of multiple myeloma who do not have any other diseases, and 2 control samples. From January 2010 to July 2012, we selected miR-15a, miR-16, miR-21, miR-181a and miR-221 as microRNA target genes. It was decided that for a sample to be significant, the results should show values more than 1.5 or less than -1.5. Our findings of fold change were highly significant in miR-15a with a value of 37.5% (3/8). From these studies, we learned that miR-15a is useful with westerners. miR-221, on the other hand, shows conflicts with westerners, so more research will be needed in this area. In addition, it was confirmed that microRNA can be detected in paraffin embedded tissue (FFPE).
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참고문헌 (25)
참고문헌 신청
Bang SM / 2006 / Identification of 13q deletion, trisomy 1q and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma / Ca
Chang HJ / 2011 / The relationship between the progression of colorectal cancer and microRNA polymorphism / Journal of Clinical Oncology 7 : 50 ~ 57
Corthals SL / 2010 / Micro-RNA-15a and micro-RNA-16expression and chromosome 13 deletions in multiple myeloma / Leukemia Resarch 34 : 677 ~ 681
Croce CM / 2009 / Causes and consequences of microRNA dysregulation in cancer / Nature Reviews Genetics 10 : 704 ~ 714
Farazi TA / 2011 / MicroRNAs in human cancer / Journal of Pathology 223 : 102 ~ 115
Chang HJ / 2011 / The relationship between the progression of colorectal cancer and microRNA polymorphism / Journal of Clinical Oncology 7 : 50 ~ 57
Corthals SL / 2010 / Micro-RNA-15a and micro-RNA-16expression and chromosome 13 deletions in multiple myeloma / Leukemia Resarch 34 : 677 ~ 681
Croce CM / 2009 / Causes and consequences of microRNA dysregulation in cancer / Nature Reviews Genetics 10 : 704 ~ 714
Farazi TA / 2011 / MicroRNAs in human cancer / Journal of Pathology 223 : 102 ~ 115
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