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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 737 - 742 (6page)
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초록· 키워드
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Cancer stem cells (CSCs) are cancer cells that possess the ability to undergo continuous proliferation and self-renewal. It has been postulated that CSCs are responsible for tumor growth, heterogeneity, invasion, metastasis, and recurrence. MicroRNAs (miRNAs), small non-coding RNAs of approximately 22 nucleotides, are known to be involved in the maintenance of CSCs. To gain insight into the role of miRNAs in CSCs, we investigated the differential expression of miRNAs in ovarian CSCs compared to non-CSCs. Ovarian CSCs were isolated from the human ovarian cancer cell line SK-OV-3 using two ovarian CSC-specific surface markers, CD44 and CD117. The expression levels of miRNAs in CSCs and non-CSCs were estimated by miRNA sequencing. We detected four up-regulated miRNAs (miR-29a-5p, miR-34c- 5p, miR-106a-5p, and miR-424-5p) in ovarian CSCs, and miR-424-5p was validated by real-time qPCR. MiR-424-5p target genes were predicted using several validated target databases and computational algorithms. Pathway analysis indicated that most miR-424-5p target genes are involved in cancer-related biological pathways. Overall, these results suggest that miR-424-5p is a potential regulator of CSCs that endows human ovarian tissue with tumorigenic potential and thus represents a potential therapeutic target for human ovarian cancer.
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참고문헌 (26)
참고문헌 신청
Alvero AB / 2009 / Molecular phenotyping of human ovarian cancer stem cells unravel the mechanisms for repair and chemo-resistance / Cell Cycle 8:158~166
Ashburner M / 2000 / Gene Ontology: tool for the unification of biology / Nat Genet 25:25~29
Bapat SA / 2010 / Human ovarian cancer stem cells / Reproduction 140:33~41
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19:185~193
Chen D / 2013 / MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117 + CD44 + ovarian cancer stem cells by regulating epithelial-mesenchymal transition / J Ovarian Res 6:50
Ashburner M / 2000 / Gene Ontology: tool for the unification of biology / Nat Genet 25:25~29
Bapat SA / 2010 / Human ovarian cancer stem cells / Reproduction 140:33~41
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19:185~193
Chen D / 2013 / MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117 + CD44 + ovarian cancer stem cells by regulating epithelial-mesenchymal transition / J Ovarian Res 6:50
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