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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 112 - 124 (13page)
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Solid tumor is generally observed in tissues of epithelial or endothelial cells of lung, breast, prostate, pancreases, colorectal, stomach, and bladder, where several genes transcription is regulated by the microRNAs (miRNAs). Argonaute (AGO) protein is a family of protein which assists in miRNAs to bind with mRNAs of the target genes. Hence, study of the binding mechanism between AGO protein and miRNAs, and also with miRNAs-mRNAs duplex is crucial for understanding the RNA silencing mechanism. In the current work, 64 genes and 23 miRNAs have been selected from literatures, whose deregulation is well established in seven types of solid cancer like lung, breast, prostate, pancreases, colorectal, stomach, and bladder cancer. In silico study reveals, miRNAs namely, miR-106a, miR-21, and miR-29b-2 have a strong binding affinity towards PTEN, TGFBR2, and VEGFA genes, respectively, suggested as important factors in RNA silencing mechanism. Furthermore, interaction between AGO protein (PDB ID-3F73, chain A) with selected miRNAs and with miRNAs-mRNAs duplex were studied computationally to understand their binding at molecular level. The residual interaction and hydrogen bonding are inspected in Discovery Studio 3.5 suites. The current investigation throws light on understanding miRNAs based gene silencing mechanism in solid cancer.
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참고문헌 (53)
참고문헌 신청
Lu Z / 2008 / MicroRNA-21promotes cell transformation by targeting the programmed cell death 4 gene / Oncogene 27:4373~4379
Xu LF / 2014 / MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China / PLoS One 9:e103698
Wang P / 2009 / microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells / Cancer Res 69:8157~8165
Li L / 2014 / MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog / J BUON 19:228~236
Chatterjee A / 2014 / miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression / PLoS One 9:e95716
Xu LF / 2014 / MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China / PLoS One 9:e103698
Wang P / 2009 / microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells / Cancer Res 69:8157~8165
Li L / 2014 / MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog / J BUON 19:228~236
Chatterjee A / 2014 / miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression / PLoS One 9:e95716
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