지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.38 No.1
- 발행연도
- 2023.3
- 수록면
- 59 - 70 (12page)
이용수
초록· 키워드
오류제보하기
Recent studies reported bisphenol A (BPA) and propyl paraben (PrP) are found in human urine, blood, and breast milk samples as well as in food, packaging, socks, and clothes. This means that the two chemicals co-exist in consumer products, and humans are exposed simultaneously to the mixture chemicals. However, the studies on the mixture effects of the two chemicals on human health are not enough. This study was designed to elucidate the effects of orally administered PrP, BPA, and their mixture effects on the uterotrophic response using ovariectomized rats. In addition, the correlation between the uterotrophic response and tissue concentrations of the two chemicals was studied to investigate whether one chemical has any effect on the absorption, distribution, or excretion of the other chemical. Histopathology, hematology, and plasma biochemistry analysis were also performed to evaluate the chemicals’ toxicological effects in the treated rats. Although a significant increase in uterus weight (absolute and relative) was observed in the positive chemical (17β-estradiol) treated group, there were no statistical differences in the uterus weight between the vehicle control and the chemical-treated groups. However, a slight increase in the endometrial glands and a change in the cuboidal to columnar epithelium of the endometrial epithelium were observed in the mixture-treated group. There was no significant toxicity in all treated groups by the hematology and plasma biochemistry analysis results. The results of tissue distribution showed that BPA was mostly detected in the liver while PrP was not detected in most tissues, and the BPA level was higher when the rats were treated with PrP than without PrP, suggesting that PrP may increase the absorption of BPA after oral administration.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusions
References
참고문헌 (32)
참고문헌 신청
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Koniecki D, Wang R, Moody RP, Zhu J. Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res 2011;111(3):329-336. https://doi.org/10.1016/j.envres.2011.01.013
Park JH, Kim JP, Kim JA, Seo KW, Kim ES, Seo JM. Survey of preservatives and UV filter ingredients of distributed sunblock products in Korea. Journal of the Society of Cosmetic Scientists of Korea 2017;43(4):381-390. https://doi.org/10.15230/SCSK.2017.43.
Soni MG, Carabin IG, Burdock GA. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 2005;43(7):985-1015. https://doi.org/10.1016/j.fct.2005.01.020
Wei F, Cheng H, Sang N. Comprehensive assessment of estrogenic activities of parabens by in silico approach and in vitro assays. Sci Total Environ 2022;845:157194. https://doi.org/10.1016/j.scitotenv.2022.157194
Koniecki D, Wang R, Moody RP, Zhu J. Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res 2011;111(3):329-336. https://doi.org/10.1016/j.envres.2011.01.013
Park JH, Kim JP, Kim JA, Seo KW, Kim ES, Seo JM. Survey of preservatives and UV filter ingredients of distributed sunblock products in Korea. Journal of the Society of Cosmetic Scientists of Korea 2017;43(4):381-390. https://doi.org/10.15230/SCSK.2017.43.
Soni MG, Carabin IG, Burdock GA. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 2005;43(7):985-1015. https://doi.org/10.1016/j.fct.2005.01.020
Wei F, Cheng H, Sang N. Comprehensive assessment of estrogenic activities of parabens by in silico approach and in vitro assays. Sci Total Environ 2022;845:157194. https://doi.org/10.1016/j.scitotenv.2022.157194
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