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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 188 - 196 (9page)
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초록· 키워드
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Purpose: To evaluate the early histological effects of the intravesical instillation of platelet-rich plasma (PRP) in rabbit models of interstitial and hemorrhagic cystitis.
Methods: Thirty-six rabbits were classified into 6 groups: saline (S), S+PRP, hydrochloric acid (HCl), HCl+PRP, cyclophosphamide (CyP), and CyP+PRP. At 48 hours after induction, PRP was prepared and intravesically administered to the S+PRP, HCl+PRP, and CyP+PRP groups. Bladder sections were stained with toluidine blue for mast cell counting and with hematoxylin and eosin for histopathology and mitotic index determination. The proliferation index was determined by proliferating cell nuclear antigen (PCNA) immunolabeling. The nonparametric Mann-Whitney U-test was used for statistical analysis.
Results: No abnormalities were observed in the S group, whereas increased interstitial edema and increased average mitotic and proliferation indices were observed in the S+PRP group (P=0.023, P=0.004, and P=0.009, respectively). Intense epithelial loss, hemorrhage, and leukocyte infiltration were detected in the HCl and HCl+PRP groups, whereas a significantly increased average mitotic index was observed in the HCl+PRP group (P=0.002). When compared with its CyP counterpart, a significant reduction in hemorrhage and an increase in leukocyte infiltration and mitotic index were observed in the CyP+PRP group (P=0.006, P=0.038, and P=0.002, respectively). In addition, PCNA staining revealed a significantly increased proliferation index in the HCl+PRP and CyP+PRP groups (P=0.032 and P=0.015, respectively).
Conclusions: The intravesical instillation of PRP increased the mitotic index in the saline and cyclophosphamide groups while decreasing macroscopic bleeding.
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참고문헌 (19)
참고문헌 신청
Oravisto KJ / 1975 / Epidemiology of interstitial cystitis / Ann Chir Gynaecol Fenn 64:75~77
Garg AK / 2000 / The use of platelet-rich plasma to enhance the success of bone grafts around dental implants / Dent Implantol Update 11:17~21
Marx RE / 2004 / Platelet-rich plasma: evidence to support its use / J Oral Maxillofac Surg 62:489~496
Sánchez AR / 2003 / Is platelet-rich plasma the perfect enhancement factor? A current review / Int J Oral Maxillofac Implants 18:93~103
Matsumoto S / 2002 / The functional and structural response to distention of the rabbit whole bladder in vitro / J Urol 168:2677~2681
Garg AK / 2000 / The use of platelet-rich plasma to enhance the success of bone grafts around dental implants / Dent Implantol Update 11:17~21
Marx RE / 2004 / Platelet-rich plasma: evidence to support its use / J Oral Maxillofac Surg 62:489~496
Sánchez AR / 2003 / Is platelet-rich plasma the perfect enhancement factor? A current review / Int J Oral Maxillofac Implants 18:93~103
Matsumoto S / 2002 / The functional and structural response to distention of the rabbit whole bladder in vitro / J Urol 168:2677~2681
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