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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 718 - 724 (7page)
이용수
초록· 키워드
오류제보하기
Background: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. Objective: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. Methods: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments. Results: Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment.
The mean MOD of collagen fibers was clearly highest on the PRP side (p＜0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected. Conclusion: PRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique ‘point by point’). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Redaelli A. / 2010 / Face and neck revitalization with platelet-rich plasma(PRP) : clinical outcome in a series of 23 consecutively treated patients / J Drugs Dermatol 9:466~472
Banihashemi M. / 2014 / An introduction to application of platelet rich plasma(PRP)in skin rejuvenation / Rev Clin Med 1:38~43
Kakudo N. / 2008 / Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts / Plast Reconstr Surg 122:1352~1360
Dae Hun Kim / 2011 / Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast / Annals of Dermatology 23(4):424~431
Cho JW. / 2012 / Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts / Int J Mol Med 29:32~36
Banihashemi M. / 2014 / An introduction to application of platelet rich plasma(PRP)in skin rejuvenation / Rev Clin Med 1:38~43
Kakudo N. / 2008 / Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts / Plast Reconstr Surg 122:1352~1360
Dae Hun Kim / 2011 / Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast / Annals of Dermatology 23(4):424~431
Cho JW. / 2012 / Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts / Int J Mol Med 29:32~36
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