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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 189 - 197 (9page)
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Purpose: Autologous platelet rich plasma (PRP) has been known to enhance tendon healing and improve tensile strength after tendon injury. This study investigated the dosage of PRP to increase the tensile strength. Methods: PRP was harvested from peripheral bloods of the rabbits. Direct injury model was adopted using 60 achilles tendons in 30 rabbits. The autologous PRP was infiltrated into the Achilles tendon repair site of four groups (control, 0.1, 0.2, 0.4 mL) with different dosages. Tendons were harvested at 2, 4 and 8 weeks and subjected to measuring mechanical tensile strength and dosage of collagen content. Results: At 2, 4, and 8 weeks, PRP administration following experimental achilles tendon repair resulted in an overall higher average tensile strength and collagen content compared to these of the control. Also, the lengthen the time, tensile strength and collagen content was increased. Conclusion: Autologous PRP enhanced tendon healing in rabbits. Within the PRP dosage setted by the author, more dosage of the infiltrated PRP increases the strength of the tendon and the dosage of collagen content. Further studies will be essential to determine the optimal dosage of PRP in clinical practice.
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참고문헌 (17)
참고문헌 신청
Yao J / 2012 / The effect of suture coated with mesenchymal stem cells and bioactive substrate on tendon repair strength in a rat model / J Hand Surg Am 37:1639~1645
Kurtz CA / 1999 / Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model / Am J Sports Med 27:363~369
Chan BP / 2000 / Effects of basic fibroblast growth factor(bFGF)on early stages of tendon healing : a rat patellar tendon model / Acta Orthop Scand 71:513~518
Suwalski A / 2010 / Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles / Biomaterials 31:5237~5245
Liu CF / 2011 / What we should know before using tissue engineering techniques to repair injured tendons : a developmental biology perspective / Tissue Eng Part B Rev 17:165~176
Kurtz CA / 1999 / Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model / Am J Sports Med 27:363~369
Chan BP / 2000 / Effects of basic fibroblast growth factor(bFGF)on early stages of tendon healing : a rat patellar tendon model / Acta Orthop Scand 71:513~518
Suwalski A / 2010 / Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles / Biomaterials 31:5237~5245
Liu CF / 2011 / What we should know before using tissue engineering techniques to repair injured tendons : a developmental biology perspective / Tissue Eng Part B Rev 17:165~176
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