Can platelet-rich plasma injections provide better pain relief and functional outcomes in persons with common shoulder diseases: a meta-analysis of randomized controlled trials

Apurba Barman; Archana Mishra; Rituparna Maiti; Jagannatha Sahoo; Kaustav Basu Thakur; Sreeja Kamala Sasidharan

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자료유형: 학술저널

저자정보: Apurba Barman (All India Institute of Medical Sciences) Archana Mishra (All India Institute of Medical Sciences) Rituparna Maiti (All India Institute of Medical Sciences) Jagannatha Sahoo (All India Institute of Medical Sciences) Kaustav Basu Thakur (All India Institute of Medical Sciences) Sreeja Kamala Sasidharan (All India Institute of Medical Sciences)

저널정보: 대한견주관절의학회 대한견주관절의학회지 대한견주관절의학회지 제25권 제1호

발행연도: 2022.3

수록면: 73 - 89 (17page)

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Background: To evaluate the efficacy of autologous platelet-rich plasma (PRP) injections in the treatment of common shoulder diseases.
Methods: The PubMed, Medline, and Central databases and trial registries were searched from their inception to October 2020 for randomized controlled trials of autologous PRP injections for shoulder diseases versus placebo or any control intervention. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were followed in the selection, analysis, and reporting of findings. The primary outcome was pain intensity (visual analog scale), and secondary outcomes were changes in function and quality of life (QoL).
Results: A total of 17 randomized controlled trials of PRP versus control were analyzed. From 8–12 weeks to ≥1 year, PRP injections were associated with better pain relief and functional outcomes than control interventions. PRP injections were also associated with greater QoL, with an effect size of 2.61 (95% confidence interval, 2.01–14.17) at medium-term follow-up. Compared with placebo and corticosteroid injections, PRP injections provided better pain relief and functional improvement. In subgroup analyses, trials in which PRP was prepared by the double centrifugation technique, the platelet concentration in the PRP was enriched ≥5 times, leucocyte-rich PRP was used, or an activating agent was used before application reported the most effective pain relief at 6–7 months.
Conclusions: PRP injections could provide better pain relief and functional outcomes than other treatments for persons presenting with common shoulder diseases. PRP injections have a greater capacity to improve shoulder-related QoL than other interventions.

#Injections #Platelet-rich plasma #Shoulder #Pain #Meta-analysis

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