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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 13 - 21 (9page)
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Platelet-rich plasma (PRP) as a source of growth factors may induce tissue repairing and improve fibrosis. This study aimed to assess the effects of PRP on kidney regeneration and fibrosis in gentamicin (GM)-induced nephrotoxicity rat model by stereological study. Thirty-two male rats were selected. Nephrotoxicity was induced in animals by administration of GM (80 mg/kg/daily, intraperitoneally [IP], 8 day) and animals were treated by PRP (100 µL, intra-cortical injection using surgical microscopy, single dose). Blood samples were collected for determine blood urea nitrogen (BUN) and creatinine (Cr) before and after PRP therapy. At the end of experiment, right kidneys were sectioned by Isotropic Uniform Random (IUR) method and stained with H & E and Masson’s Trichrome. The stereological methods were used for estimating the changes in different structures of kidney. PRP increased the number of epithelial cells in convoluted tubules, and decreased the volume of connective tissue, renal corpuscles and glomeruli in GM-treated animals (P < 0.05). Our findings indicate that PRP had beneficial effects on proliferation of epithelial cells in convoluted tubules and ameliorated GM-induced fibrosis.
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참고문헌 (28)
참고문헌 신청
Fortier LA / 2011 / The role of growth factors in cartilage repair / Clin Orthop Relat Res 469:2706~2715
Lyras DN / 2009 / The influence of platelet-rich plasma on angiogenesis during the early phase of tendon healing / Foot Ankle Int 30:1101~1106
Kark LR / 2006 / Platelet releasate increases the proliferation and migration of bone marrow-derived cells cultured under osteogenic conditions / Clin Oral Implants Res 17:321~327
Debus ES / 2001 / Growth factors for preventing amputation in delayed wound healing / Kongressbd Dtsch Ges Chir Kongr 118:829~833
Peerbooms JC / 2010 / Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial : platelet-rich plasma versus corticosteroid injection with a 1-year follow-up / Am J Sports Med 38:255~262
Lyras DN / 2009 / The influence of platelet-rich plasma on angiogenesis during the early phase of tendon healing / Foot Ankle Int 30:1101~1106
Kark LR / 2006 / Platelet releasate increases the proliferation and migration of bone marrow-derived cells cultured under osteogenic conditions / Clin Oral Implants Res 17:321~327
Debus ES / 2001 / Growth factors for preventing amputation in delayed wound healing / Kongressbd Dtsch Ges Chir Kongr 118:829~833
Peerbooms JC / 2010 / Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial : platelet-rich plasma versus corticosteroid injection with a 1-year follow-up / Am J Sports Med 38:255~262
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Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats
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Knee Surgery and Related Research
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Effect of autologous platelet-rich plasma application on cutaneous wound healing in dogs
Journal of Veterinary Science
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Relation of cytokines and clinical effect on Platelet-rich Plasma (PRP) treated Lateral epicondylitis
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The Effect of Platelet Rich Plasma Dosage on the Tendon Healing in Rabbits
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Platelet-rich plasma versus corticosteroid injections for rotator cuff tendinopathy: a comparative study with up to 18-month follow-up
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The benefit of platelet-rich plasma injection over institutionbased physical therapy program in adhesive capsulitis patients with diabetes mellitus: prospective observational cohort study
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Effect of autologous platelet-rich plasma for treatment of recurrent pregnancy loss: a randomized controlled trial
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Current clinical applications of platelet-rich plasma in various gynecological disorders: An appraisal of theory and practice
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