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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,195 - 1,203 (9page)
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Purpose: To investigate whether autologous platelet-rich plasma (PRP) treatment can improve regeneration of the endometrium in an experimental model of ethanol-induced damage.
Materials and Methods: Sixty female Sprague-Dawley rats were randomly assigned into three groups: control group, ethanol group, and PRP-treated group (administration of 0.25 mL of PRP into both uterine cavities 72 hours after ethanol injection). After 15 days of endometrial damage, all the animals were sacrificed during the estrous cycle, and samples were taken from the mid-uterine horn. Functional and structural recovery of the endometrium was analyzed by hematoxylin-eosin (H&E) and Masson trichrome(MT) staining, real-time polymerase chain reaction (PCR) assay, and immuno-histochemical (IHC) analyses.
Results: H&E and MT staining confirmed significantly decreased fibrosis and increased cellular proliferation in the PRP-treated group, compared to the ethanol group. The endometrial areas in the ethanol and PRP-treated groups were 212.83±15.84 μm2 and 262.34±12.33 μm2 (p=0.065). Significantly stronger IHC expression of cytokeratin, homeobox A10 (HOXA10), vascular endothelial growth factor (VEGF), and Ki-67 was found in the PRP-treated group, compared to the ethanol group. In real-time PCR analyses, interleukin-1β mRNA was down-regulated, while c-Kit mRNA was up-regulated, in the PRP-treated group, compared to the ethanolgroup.
Conclusion: Intrauterine administration of autologous PRP stimulated and accelerated regeneration of the endometrium and also decreased fibrosis in a murine model of damaged endometrium.
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참고문헌 (40)
참고문헌 신청
Terada S / 2013 / Use of an antifibrotic agent improves the effect of plateletrich plasma on muscle healing after injury / J Bone Joint Surg Am 95:980~988
Varghese F / 2014 / IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples / PLoS One 9:e96801
Tuominen VJ / 2010 / ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 / Breast Cancer Res 12:R56
Surrey ES / 1991 / Effect of platelet-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis? / Fertil Steril 56:672~679
Munson L / 1995 / Platelet-derived growth factor promotes endometrial epithelial cell proliferation / Am J Obstet Gynecol 173:1820~1825
Varghese F / 2014 / IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples / PLoS One 9:e96801
Tuominen VJ / 2010 / ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 / Breast Cancer Res 12:R56
Surrey ES / 1991 / Effect of platelet-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis? / Fertil Steril 56:672~679
Munson L / 1995 / Platelet-derived growth factor promotes endometrial epithelial cell proliferation / Am J Obstet Gynecol 173:1820~1825
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