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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 191 - 199 (9page)
- DOI
- 10.1186/s40824-016-0071-5
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이 논문의 연구 히스토리 (4)
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초록· 키워드
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After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared using heat-pressing and salt-leaching methods. High-density polyethylene (HDPE) and poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for producing a porous scaffold of high mechanical strength and having high reactivity with biomaterials such as collagen, respectively. The porous structure was observed through surface images, and its intrusion volume and porosity were measured. Owing to the carboxylic acids on PEAA, collagen was successfully grafted onto the porous HDPE/PEAA scaffold, which was confirmed by FT-IR spectroscopy and electron spectroscopy for chemical analysis. Osteoblasts were cultured on the collagen-grafted porous scaffold, and their adhesion, proliferation, and differentiation were investigated. The high viability and growth of the osteoblasts suggest that the collagen-grafted porous HDPE/PEAA is a promising scaffold material for bone generation.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Imola MJ / 2003 / Skull base reconstruction / Curr Opin Otolaryngol Head Neck Surg 11(4):282~290
Abdurrahim T / 2008 / Recent progress on the development of porous bioactive calcium phosphate for biomedical applications / Recent Pat Biomed Eng 1(3):213~229
Mour MD / 2010 / Advances in porous biomaterials for dental and orthopaedic applications / Materials 3:2947~2974
Chua C / 2001 / The design of scaffolds for use in tissue engineering. Part i. Traditional factors / Tissue Eng 7:679~689
Ciara FJOB / 2010 / Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds / Cell Adhes Migr 4:377~381
Abdurrahim T / 2008 / Recent progress on the development of porous bioactive calcium phosphate for biomedical applications / Recent Pat Biomed Eng 1(3):213~229
Mour MD / 2010 / Advances in porous biomaterials for dental and orthopaedic applications / Materials 3:2947~2974
Chua C / 2001 / The design of scaffolds for use in tissue engineering. Part i. Traditional factors / Tissue Eng 7:679~689
Ciara FJOB / 2010 / Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds / Cell Adhes Migr 4:377~381
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