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Bioceramic hydroxyapatite-based scaffold with a porous structure using honeycomb as a natural polymeric Porogen for bone tissue engineering
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논문 기본 정보

Type
Academic journal
Author
Mona Sari (Universitas Gadjah Mada Indonesia) Puspa Hening (Universitas Gadjah Mada Indonesia) Ika Dewi Ana (Universitas Gadjah Mada Indonesia) Yusril Yusuf (Universitas Gadjah Mada Indonesia)
Journal
한국생체재료학회 생체재료학회지 생체재료학회지 제25권 제1호 KCI Accredited Journals
Published
2021.1
Pages
47 - 59 (13page)

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Bioceramic hydroxyapatite-based scaffold with a porous structure using honeycomb as a natural polymeric Porogen for bone tissue engineering
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Background: The application of bioceramic hydroxyapatite (HA) derived from materials high in calcium to tissue engineering has been of concern, namely scaffold. Scaffold pores allow for cell mobility metabolic processes, and delivery of oxygen and nutrients by blood vessel. Thus, pore architecture affects cell seeding efficiency, cell viability, migration, morphology, cell proliferation, cell differentiation, angiogenesis, mechanical strength of scaffolds, and, eventually, bone formation. Therefore, to improve the efficacy of bone regeneration, several important parameters of the pore architecture of scaffolds must be carefully controlled, including pore size, geometry, orientation, uniformity, interconnectivity, and porosity, which are interrelated and whose coordination affects the effectiveness of bone tissue engineering. The honeycomb (HCB) as natural polymeric porogen is used to pore forming agent of scaffolds. It is unique for fully interconnected and oriented pores of uniform size and high mechanical strength in the direction of the pores. The aim of this study was therefore to evaluate the effect of HCB concentration on macropore structure of the scaffolds. Methods: Bioceramic hydroxyapatite (HA) was synthesized from abalone mussel shells (Halioitis asinina) using a precipitation method, and HA-based scaffolds were fabricated with honeycomb (HCB) as the porogen agent. Pore structure engineering was successfully carried out using HCB at concentrations of 10, 20, and 30 wt%. Results: The Energy Dispersive X-Ray Spectroscopy (EDS) analysis revealed that the Ca/P molar ratio of HA was 1.67 (the stoichiometric ratio of HA). The Fourier Transform Infrared Spectroscopy (FTIR) spectra results for porous HAbased scaffolds and synthesized HA showed that no chemical decomposition occurred in the HA-based scaffold fabrication process. The porosity of the scaffold tended to increase when higher concentrations of HCB were added. XRD data show that the HCB was completely degraded from the scaffold material. The cell metabolic activity and morphology of the HA + HCB 30 wt% scaffold enable it to facilitate the attachment of MC3T3E1 cells on its surface. Conclusion: HCB 30 wt% is the best concentration to fabricate the scaffold corresponding to the criteria for pores structure, crystallographic properties, chemical decomposition process and cell viability for bone tissue engineering.
#Hydroxyapatite #Scaffold #Abalone mussel shells #Honeycomb #Bone tissue engineering

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References (34)

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Mawuntu VJ / 2019 / Porous structure engineering of bioceramic hydroxyapatite-based scaffolds using PVA, PV, and PEO as polymeric porogens / J Asian Ceram Soc 7(2):1~9 Crossref Mawuntu VJ / 2018 / Porous-structure engineering of hydroxyapatite-based scaffold synthesized from Pomacea canaliculata shell by using polyethylene oxide as polymeric porogen / IOP Conference Series Mater Sci Eng :432 google schola Ana ID / 2018 / Bioceramics for clinical application in regenerative dentistry / Springer Nature Singapore Pte Ltd :309~316 google schola Ana ID / 2019 / Bone substituting materials in dental implantology / Springer Nature Switzerland AG google schola Govindan Suresh Kumar / 2017 / One step method to synthesize flower-like hydroxyapatite architecture using mussel shell bio-waste as a calcium source / Ceramics International 43(3):3457~3461 Crossref

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