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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 279 - 289 (11page)
- DOI
- https://doi.org/10.1186/s40824-018-0136-8
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초록· 키워드
오류제보하기
Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need. Main body: This review highlights the relationship between the scaffold microstructure and cell behavior, and provides the basics of the micro-CT method. In this work, we also analyzed the original papers that were published in 2016 through a systematic search to address the need for specific improvements in the methods section of the papers including the amount of provided information from the obtained results. Conclusion: Micro-CT offers a unique microstructural analysis of biomaterials, notwithstanding the associated challenges and limitations. Future studies that will include micro-CT characterization of scaffolds should report the important details of the method, and the derived quantitative and qualitative information can be maximized.
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참고문헌 (171)
참고문헌 신청
Wegst UG / 2015 / Bioinspired structural materials / Nat Mater 14(1):23~36
Lee J / 2008 / Three-dimensional cell culture matrices : State of the art / Tissue Eng Part B-Re 14(1):61~86
Baker BM / 2012 / Deconstructing the third dimension-How 3D culture microenvironments alter cellular cues / J Cell Sci 125(13):3015~3024
Cengiz IF / 2018 / Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room / J Exp Orthop 5(1):14
Chew SY / 2011 / Scaffold-based approach to direct stem cell neural and cardiovascular differentiation : An analysis of physical and biochemical effects / J Biomed Mater Res A 97(3):355~374
Lee J / 2008 / Three-dimensional cell culture matrices : State of the art / Tissue Eng Part B-Re 14(1):61~86
Baker BM / 2012 / Deconstructing the third dimension-How 3D culture microenvironments alter cellular cues / J Cell Sci 125(13):3015~3024
Cengiz IF / 2018 / Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room / J Exp Orthop 5(1):14
Chew SY / 2011 / Scaffold-based approach to direct stem cell neural and cardiovascular differentiation : An analysis of physical and biochemical effects / J Biomed Mater Res A 97(3):355~374
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