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MG-63 osteoblast-like cell proliferation on auxetic PLGA scaffold with mechanical stimulation for bone tissue regeneration
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Type
Academic journal
Author
Hong Jin Choi (인제대학교) 이준재 (인제대학교) 박영준 (인제대학교) Shin Jung Woog (인제대학교) Sung Hak-Joon (연세대학교) JiWon Shin (인제대학교) Yan Ru Wu (인제대학교) Jeong Koo Kim (인제대학교)
Journal
한국생체재료학회 생체재료학회지 생체재료학회지 제20권 제4호 KCI Accredited Journals
Published
2016.12
Pages
294 - 301 (8page)
DOI
10.1186/s40824-016-0080-4

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MG-63 osteoblast-like cell proliferation on auxetic PLGA scaffold with mechanical stimulation for bone tissue regeneration
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Background: Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation. Methods: Negative Poisson’s ratio in scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature (60 °C). The pore size of scaffold ranged between 355 and 400 μm. Results: The porous morphology of the prepared auxetic scaffolds had shown partially concave and dent shapes in SEM image as expected. The lowest Poisson’s ratios of experimental group was ?0.07 at 60 °C/10 min. Compressive strength of experimental group was shown about 3.12 times higher than control group (conventional scaffold) in dry state at 25 °C. The compressive strengths of both groups were tended to be decreased dramatically in wet state compared to in dry state. However, compressive strengths of experimental group were higher 3.08 times and 1.88 times in EtOH/PBS (25 °C) and EtOH/PBS/DMEM (37 °C) than control group in wet state, respectively. Degradation rate of the scaffolds showed about 16 % weight loss in 5 weeks. In cell attachment test, experimental group showed 1.46 times higher cell proliferation than control group at 1-day with compressive stimulation. In 3-day culture, the experimental group showed 1.32 times higher than control group. However, there was no significant difference in cell proliferation in 5-day cultivation. Conclusion: Overall, negative Poisson’s ratio scaffolds with static mechanical stimulation could affect the cell proliferation at initial cultivation time.
#Negative Poisson's ratio #MG-63 cell #Mechanical stimulation

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References (16)

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Yoon JJ / 2001 / Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts / J Biomed Mater Res 55:401~408 google schola Jun Jae Lee / 2007 / Investigation on biodegradable PLGA scaffold with various pore size structure for skin tissue engineering / Current Applied Physics 7(s1):37~40 google schola Oh SH / 2007 / In vitro and in vivo characteristic of PCL scaffold with pore size gradient fabricated by a centrifugation method / Biomaterials 28:1664~1671 google schola Hou Q / 2003 / Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique / Biomaterials 24:1937~1947 google schola Wu L / 2006 / “Wet-state” mechanical properties of threedimensional polyester porous scaffolds / J Biomed Mater Res 76A:264~271 google schola

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