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논문 기본 정보

자료유형
학술저널
저자정보
Yuliet Montoya (Universidad Pontificia Bolivariana Medellín Colombia) José Cardenas (Universidad Pontificia Bolivariana Medellín Colombia) John Bustamante (Universidad Pontificia Bolivariana Medellín Colombia) Raúl Valencia (Universidad Pontificia Bolivariana Medellín Colombia)
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한국생체재료학회 생체재료학회지 생체재료학회지 제25권 제4호
발행연도
2021.12
수록면
529 - 545 (17page)
DOI
https://doi.org/10.1186/s40824-021-00240-8

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Background: Nowadays, the engineering vascular grafts with a diameter less than 6 mm by means of electrospinning, is an attracted alternative technique to create different three-dimensional microenvironments with appropriate physicochemical properties to promote the nutrient transport and to enable the bioactivity, dynamic growth and differentiation of cells. Although the performance of a well-designed porous wall is key for these functional requirements maintaining the mechanical function, yet predicting the flow rate and cellular transport are still not widely understood and many questions remain open about new configurations of wall can be used for modifying the conventional electrospun samples. The aim of the present study was to evaluate the effect of fabrication techniques on scaffolds composed of bovine gelatin and polycaprolactone (PCL) developed by sequential electrospinning and co electrospinning, on the morphology and fluid-mechanical properties of the porous wall. Methodology: For this purpose, small diameter tubular structures were manufactured and experimental tests were performed to characterize the crystallinity, morphology, wettability, permeability, degradability, and mechanical properties. Some samples were cross-linked with Glutaraldehyde (GA) to improve the stability of the gelatin fiber. In addition, it was analyzed how the characteristics of the scaffold favored the levels of cell adhesion and proliferation in an in vitro model of 3T3 fibroblasts in incubation periods of 24, 48 and 72 h. Results: It was found that in terms of the morphology of tubular scaffolds, the co-electrospun samples had a better alignment with higher values of fiber diameters and apparent pore area than the sequential samples. The static permeability was more significant in the sequential scaffolds and the hydrophilic was higher in the co-electrospun samples. Therefore, the gelatin mass losses were less in the co-electrospun samples, which promote cellular functions. In terms of mechanical properties, no significant differences were observed for different types of samples. Conclusion: This research concluded that the tubular scaffolds generated by sequential and co-electrospinning with modification in the microarchitecture could be used as a vascular graft, as they have better permeability and wettability, interconnected pores, and a circumferential tensile strength similar to native vessel compared to the commercial graft analyzed.
#Small diameter vascular graft #Sequential and co-electrospinning #Morphology of scaffolds #Physicochemical properties #Fluid-mechanical properties

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참고문헌 (64)

참고문헌 신청
Carrabba M / 2018 / Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts / Front Bioeng Biotechnol 6:41 google schola Yazdanpanah A / 2015 / Fabrication and characterization of electrospun poly-L-lactide/gelatin graded tubular scaffolds : Toward a new design for performance enhancement in vascular tissue engineering / Prog Nat Sci Mater Int 25:405~413 google schola Stefani I / 2016 / Development of an in-process UV-crosslinked, electrospun PCL/aPLA-co-TMC composite polymer for tubular tissue engineering applications / Acta Biomater 36:231~240 google schola World Health Organization / Cardiovascular diseases (CVDs) google schola Greisler HP / 2003 / Vascular grafts : experiment and modeling / J Vasc Surg 38:1144 google schola

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