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논문 기본 정보

자료유형
학술저널
저자정보
Umberto Garagiola (Biomedical Surgical and Dental Sciences Department Maxillo-Facial an) Roberto Grigolato (Biomedical Surgical and Dental Sciences) Rossano Soldo (Biomedical Surgical and Dental Sciences) Marco Bacchini (Private Practice Milan Italy.) Gianluca Bassi (Biomedical Surgical and Dental Sciences) Rachele Roncucci (Biomedical Surgical and Dental Sciences) Sandro De Nardi (Private Practice Milan Italy.)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제37권 제12호
발행연도
2015.12
수록면
1 - 9 (9page)
DOI
10.1186/s40902-015-0048-7

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Background: We reviewed the biological and mechanical properties of porous hydroxyapatite (HA) compared toother synthetic materials. Computer-aided design/computer-aided manufacturing (CAD/CAM) was also evaluated toestimate its efficacy with clinical and radiological assessments. Method: A systematic search of the electronic literature database of the National Library of Medicine (PubMed-MEDLINE) was performed for articles published in English between January 1985 and September 2013. The inclusioncriteria were (1) histological evaluation of the biocompatibility and osteoconductivity of porous HA in vivo and in vitro,(2) evaluation of the mechanical properties of HA in relation to its porosity, (3) comparison of the biological andmechanical properties between several biomaterials, and (4) clinical and radiological evaluation of the precision ofCAD/CAM techniques. Results: HA had excellent osteoconductivity and biocompatibility in vitro and in vivo compared to other biomaterials. HA grafts are suitable for milling and finishing, depending on the design. In computed tomography, porous HA is amore resorbable and more osteoconductive material than dense HA; however, its strength decreases exponentiallywith an increase in porosity. Conclusions: Mechanical tests showed that HA scaffolds with pore diameters ranging from 400 to 1200 μm hadcompressive moduli and strength within the range of the human craniofacial trabecular bone. In conclusion, usingCAD/CAM techniques for preparing HA scaffolds may increase graft stability and reduce surgical operating time.

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