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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 35 - 44 (10page)
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초록· 키워드
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Mitochondria are responsible for supplying of most of the cell’s energy via oxidative phosphorylation. However, mitochondria also can be deleterious for a cell because they are the primary source of reactive oxygen species, which are generated as a byproduct of respiration. Accumulation of mitochondrial and cellular oxidative damage leads to diverse pathologies. Thus, it is important to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Eukaryotes have developed defense mechanisms to cope with aberrant mitochondria. Mitochondria autophagy (known as mitophagy) is thought to be one such process that selectively sequesters dysfunctional or excess mitochondria within double-membrane autophagosomes and carries them into lysosomes/vacuoles for degradation. The power of genetics and conservation of fundamental cellular processes among eukaryotes make yeast an excellent model for understanding the gen-eral mechanisms, regulation, and function of mitophagy. In budding yeast, a mitochondrial surface protein, Atg32, serves as a mitochondrial receptor for selective autophagy that interacts with Atg11, an adaptor protein for selective types of autophagy, and Atg8, a ubiquitin-like protein localized to the isolation membrane. Atg32 is regulated transcriptionally and post-translationally to control mitophagy. Moreover, because Atg32 is a mitophagy-specific protein, analysis of its deficient mutant enables investigation of the physiological roles of mitophagy. Here, we review recent progress in the understanding of the molecular mechanisms and functional importance of mitophagy in yeast at multiple levels.
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참고문헌 (89)
참고문헌 신청
Abeliovich, H. / 2013 / Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy / Nat. Commun. 4:2789
Aihara, M. / 2014 / Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast / J. Cell Sci. 127:3184~3196
Aoki, Y. / 2011 / Phosphorylation of Serine 114 on Atg32 mediates mitophagy / Mol. Biol. Cell 22:3206~3217
Barth, P.G. / 1983 / An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes / J. Neurol. Sci. 62:327~355
Belgareh-Touze, N. / 2017 / Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy / Autophagy 13:114~132
Aihara, M. / 2014 / Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast / J. Cell Sci. 127:3184~3196
Aoki, Y. / 2011 / Phosphorylation of Serine 114 on Atg32 mediates mitophagy / Mol. Biol. Cell 22:3206~3217
Barth, P.G. / 1983 / An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes / J. Neurol. Sci. 62:327~355
Belgareh-Touze, N. / 2017 / Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy / Autophagy 13:114~132
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